Mavacamten, also known as SAR-439152 and MYK-461, is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy. SAR-439152 reduces contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.
MedKoo Cat#: 527002
Name: Mavacamten
CAS#: 1642288-47-8
Chemical Formula: C15H19N3O2
Exact Mass: 273.1477
Molecular Weight: 273.34
Elemental Analysis: C, 65.91; H, 7.01; N, 15.37; O, 11.71
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 33.0 | 120.73 | ||
| DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.83 | ||
| DMSO | 52.8 | 193.08 | ||
| Ethanol | 3.0 | 10.98 |
The following data is based on the product molecular weight 273.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
