Synonym
Ro 23-7637; Ro 237637; Ro-23-7637.
IUPAC/Chemical Name
4-(2,2-Diphenylethenyl)-1-(1-oxo-9-(3-pyridinyl)nonyl)piperidine
InChi Key
NHKWRRHZTGQJMT-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H40N2O/c36-33(20-12-4-2-1-3-7-14-29-15-13-23-34-27-29)35-24-21-28(22-25-35)26-32(30-16-8-5-9-17-30)31-18-10-6-11-19-31/h5-6,8-11,13,15-19,23,26-28H,1-4,7,12,14,20-22,24-25H2
SMILES Code
N1(CCC(CC1)\C=C(\c1ccccc1)c1ccccc1)C(CCCCCCCCc1cnccc1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
480.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: White JD, Blakemore PR, Milicevic S, Choudhry SC, Cupano J, Serico L. Conversion of carbamates to amidosulfones and amides. Synthesis of the [14C]-labeled antiobesity agent Ro23-7637. Org Lett. 2002 May 16;4(10):1803-6. PubMed PMID: 12000303.
2: Ghosal A, Satoh H, Thomas PE, Bush E, Moore D. Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450. Drug Metab Dispos. 1996 Sep;24(9):940-7. PubMed PMID: 8886602.
3: Campfield LA, Smith FJ, Mackie G, Tenenbaum R, Sassano ML, Mullin J, Kaiser K, Kierstead RW. Insulin normalization as an approach to the pharmacological treatment of obesity. Obes Res. 1995 Nov;3 Suppl 4:591S-603S. PubMed PMID: 8697062.
4: Szuna AJ, Mulligan TE, Mico BA, Blain RW. Determination of Ro 23-7637 in dog plasma by multidimensional ion-exchange-reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1993 Jul 2;616(2):297-303. PubMed PMID: 8376510.
