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MedKoo Cat#: 526173 | Name: Ro 23-7014

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 23-7014 is a new thiazepinone Ca2+ channel antagonist that has high affinity for peripheral (Type A) receptors.

Chemical Structure

Ro 23-7014
Ro 23-7014
CAS#113714-78-6

Theoretical Analysis

MedKoo Cat#: 526173

Name: Ro 23-7014

CAS#: 113714-78-6

Chemical Formula: C48H63N9O16S4

Exact Mass: 1149.3276

Molecular Weight: 1150.32

Elemental Analysis: C, 50.12; H, 5.52; N, 10.96; O, 22.25; S, 11.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 23-7014; Ro 237014; Ro-23-7014.
IUPAC/Chemical Name
Acetyl-O-sulfo-tyrosyl-methionyl-glycyl-tryptophyl-methionyl-O-sulfo-threonyl-N-methyl(phenylalaninamide)
InChi Key
QLLNZWDONKQEDH-FSFWIGPWSA-N
InChi Code
InChI=1S/C48H63N9O16S4/c1-28(72-76(66,67)68)41(46(64)57(3)48(29(2)58,47(50)65)25-31-11-7-6-8-12-31)56-44(62)38(20-22-75-5)55-45(63)39(24-32-26-51-36-14-10-9-13-34(32)36)53-40(59)27-52-43(61)37(19-21-74-4)54-42(60)35(49)23-30-15-17-33(18-16-30)73-77(69,70)71/h6-18,26,28,35,37-39,41,51H,19-25,27,49H2,1-5H3,(H2,50,65)(H,52,61)(H,53,59)(H,54,60)(H,55,63)(H,56,62)(H,66,67,68)(H,69,70,71)/t28-,35+,37+,38+,39+,41+,48-/m1/s1
SMILES Code
O=C(N)[C@@](CC1=CC=CC=C1)(C(C)=O)N(C([C@H]([C@H](OS(=O)(O)=O)C)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCSC)NC([C@H](CC4=CC=C(OS(=O)(O)=O)C=C4)N)=O)=O)=O)=O)=O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,150.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sordahl LA, Rex KA, Benedict CR. In vivo inhibition of platelet aggregation and occlusive coronary thrombus formation by a new calcium antagonist (R023-6152). J Cardiovasc Pharmacol. 1991 Oct;18(4):504-10. PubMed PMID: 1724526. 2: Medh JD, Rex KA, Benedict CR, Sordahl LA. In vitro and in vivo effects of R023-6152 on heart mitochondrial calcium and energy metabolism. J Cardiovasc Pharmacol. 1991 Oct;18(4):473-7. PubMed PMID: 1724522. 3: Folkers HB, van Zwienen JC, Boer P, Kleinbloesem CH, Geyskes GG. Hemodynamic effects of Ro 23-6152 in patients with essential hypertension. Eur J Clin Pharmacol. 1991;41(4):307-11. PubMed PMID: 1804644.