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MedKoo Cat#: 414139 | Name: Ethonium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ethonium is an antimicrobial drug of the group of cationic surface-active substances. Ethonium possesses a marked antiradical and antioxidant effect in ulcer disease, furthering potentiation of the activity of peroxidedysmutase, protective enzymes of the glutathione system, improvement of bioenergetic processes in the gastric mucosa, enhancement of ulcer healing, and prevention of ulcer recurrence.

Chemical Structure

Ethonium
Ethonium
CAS#21954-74-5 (chloride)

Theoretical Analysis

MedKoo Cat#: 414139

Name: Ethonium

CAS#: 21954-74-5 (chloride)

Chemical Formula: C30H62Cl2N2O4

Exact Mass: 584.4087

Molecular Weight: 585.74

Elemental Analysis: C, 61.52; H, 10.67; Cl, 12.10; N, 4.78; O, 10.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
27925-85-5 (cation) 21954-74-5 (chloride)
Synonym
Ethonium; Etonium; Ethonium chloride;
IUPAC/Chemical Name
1,2-Ethanediaminium, N,N'-bis(2-(decyloxy)-2-oxoethyl)-N,N,N',N'-tetramethyl-, dichloride
InChi Key
UPCOSYBELNEQAU-UHFFFAOYSA-L
InChi Code
InChI=1S/C30H62N2O4.2ClH/c1-7-9-11-13-15-17-19-21-25-35-29(33)27-31(3,4)23-24-32(5,6)28-30(34)36-26-22-20-18-16-14-12-10-8-2;;/h7-28H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
C[N+](C)(CC(OCCCCCCCCCC)=O)CC[N+](C)(CC(OCCCCCCCCCC)=O)C.[Cl-].[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 585.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pis'ko GT. Etoniĭ [Ethonium]. Vrach Delo. 1977 Mar;(3):4-9. Russian. PMID: 855290. 2: Zhernosekova IV, Kukushkina NV, Babenko IuS. Vliianie étoniia na liziruemost' kletok stafilokokka fermentnym preparatom shtamma Streptomyces recifensis subsp. lyticus [Effect of ethonium on the lysability of staphylococcal cells by an enzyme preparation of the strain Streptomyces recifensis subsp. lyticus]. Antibiot Khimioter. 1990 Nov;35(11):10-3. Russian. PMID: 2092628. 3: Gudz' OV, Pis'ko GT. Sovmestnoe deĭstvie étoniia i antibiotikov na grampolozhitel'nye i gramotritsatel'nye mikroorganizmy [Joint action of ethonium and antibiotics on gram-positive and gram-negative microorganisms]. Antibiotiki. 1982;27(9):672-4. Russian. PMID: 6756299. 4: KUPERMAN AS, OKAMOTO M. A COMPARISON OF THE EFFECTS OF SOME ETHONIUM IONS AND THEIR STRUCTURAL ANALOGUES ON NEUROMUSCULAR TRANSMISSION IN THE CAT. Br J Pharmacol Chemother. 1965 Feb;24(1):223-39. doi: 10.1111/j.1476-5381.1965.tb02098.x. PMID: 14302356; PMCID: PMC1704058. 5: Kavkalo DN. Lechenie gnoĭnykh ran étoniem [Treatment of purulent wounds with ethonium]. Klin Khir (1962). 1984 Jan;(1):47-9. Russian. PMID: 6708328. 6: Gladyshevskaia-Veselovska, Pisko GT. Chutlyvist' klebsiella do etoniiu v doslikadkh in vitro ta in vivo [Sensitivity of Klebsiella to ethonium in experiments in vitro and in vivo]. Mikrobiol Zh. 1970 Sep-Oct;32(5):649-50. Ukrainian. PMID: 5517684. 7: Lidvanskaia LS, Koren' VS. Etoniĭ v lechenii i profilaktike ostrykh pnevmoniĭ [Ethonium in the prevention and treatment of acute pneumonia]. Ter Arkh. 1978;50(3):49-51. Russian. PMID: 653595. 8: Mogilevich SE, Galushko SV, Klebanov BM. Farmakokinetika étoniia pri peroral'nom vvedenii [Pharmacokinetics of ethonium administered perorally]. Farmakol Toksikol. 1987 Mar-Apr;50(2):82-4. Russian. PMID: 3582639. 9: Tretiak EM, Ozerianskaia NM, Bidnenko SI, Novikova OA. Vliianie biologicheskikh zhidkosteĭ organizma na antimikrobnuiu aktivnost' modifitsirovannogo étoniem shovnogo materiala [Effect of biological fluids of the body on antimicrobial activity of ethonium-modified suture material]. Klin Khir (1962). 1992;(1):14-5. Russian. PMID: 1564854. 10: Radzikhovskiĭ BL, Titenko KS, Lovlia GD. Primenenie novogo preparata étoniia pri nekotorykh zabolevaniiakh perednego otrezka glaza [Application of the new preparation ethonium in certain diseases of the anterior segment of the eye]. Oftalmol Zh. 1969;24(2):85-9. Russian. PMID: 5807051. 11: Tydel'skaia IL, Rozhavin MA, Sologub VV. Selektivnaia sreda s étoniem i penitsillinom dlia vyrashchivaniia Pseudomonas aeruginosa [Selective ethonium and penicillin medium for growing Pseudomonas aeruginosa]. Lab Delo. 1980;(9):549-50. Russian. PMID: 6157928. 12: Borima TV, Nitsovich RM, Batiuk TK, Pis'ko GT. Zastosuvannia etoniiu v akushers'ko-ginekologichniĭ praktitsi [Use of ethonium in obstetrics- gynecology]. Pediatr Akus Ginekol. 1969 Jul-Aug;4:42-4. Ukrainian. PMID: 5391715. 13: Shestakov PK. Primenenie pasty etoniia pri lechenii glubokolo a riesa zubov [The use of ethonium paste in the treatment of deep dental caries]. Stomatologiia (Mosk). 1971 Mar-Apr;50(2):79-80. Russian. PMID: 5291203. 14: Gezunterman PI, Poliakova NN. Lechenie ostrykh rinitov u deteĭ élektroaérozoliami étoniia [Treatment of acute rhinitis in children by means of ethonium electroaerosols]. Zh Ushn Nos Gorl Bolezn. 1975 Nov-Dec;(6):79. Russian. PMID: 1227143. 15: Khrystych TM. Sezonni kolyvannia zovnishn'osekretornoï funktsiï pidshlunkovoï zalozy, stan antyoksydantnoï systemy zakhistu ta efektyvnist' etoniiu pry khronichnomu pankreatyti [Seasonal fluctuations in the exocrine function of the pancreas, the state of the antioxidant system of protection and the efficacy of ethonium in chronic pancreatitis]. Lik Sprava. 2000 Jul- Aug;(5):77-80. Ukrainian. PMID: 11031458. 16: Paliĭ GK, Iakovleva AM, Sidorchuk II, Pishak VP, Polivoda NG. Tsitogeneticheskoe deĭstvie étoniia, dekametoksina i proizvodnogo geksametilendiamina [Cytogenetic action of ethonium, decamethoxin and a hexamethylene diamine derivative]. Genetika. 1974 Jan;10(1):171-2. Russian. PMID: 4469505. 17: EDWARDS D, LEWIS JJ, STENLAKE JB, ZOHA MS. Neuromuscular blocking agents. II. The preparation and properties of a series of NSN- and NNN-tris-ethonium compounds. J Pharm Pharmacol. 1958 Dec;10(Supp):106-21T. PMID: 13611660. 18: Kucher VI. Nabuttia rezystentnosti stafilokokamy do etoniiu ta deiakykh antybiotykiv [Resistance of staphylococci to ethonium and some antibiotics]. Mikrobiol Zh. 1970 May-Jun;32(4):502-5. Ukrainian. PMID: 5205114. 19: Sidorchuk II, Volianskiĭ IuL. Razvitie ustoĭchivosti stafilokokkov k etoniiu i nekotorym antibiotikam [Development of staphylococcal resistance to ethonium and some antibiotics]. Antibiotiki. 1971;16(4):302-4. Russian. PMID: 4936026. 20: Kolomoets MIu. Etoniĭ v lechenii bol'nykh iazvennoĭ bolezn'iu [Ethonium in the treatment of peptic ulcer patients]. Lik Sprava. 1992 May;(5):65-9. Russian. PMID: 1441415.