Synonym
RG 6866; RG6866; RG-6866.
IUPAC/Chemical Name
Benzeneacetamide, N-hydroxy-N-methyl-4-(phenylmethoxy)-
InChi Key
MYMPWMRYZURXNI-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17NO3/c1-17(19)16(18)11-13-7-9-15(10-8-13)20-12-14-5-3-2-4-6-14/h2-10,19H,11-12H2,1H3
SMILES Code
O=C(N(O)C)CC1=CC=C(OCC2=CC=CC=C2)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
271.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gleason MM, Rojas CJ, Learn KS, Perrone MH, Bilder GE. Characterization and inhibition of 15-lipoxygenase in human monocytes: comparison with soybean 15-lipoxygenase. Am J Physiol. 1995 May;268(5 Pt 1):C1301-7. PubMed PMID: 7762624.
2: Folcik VA, Cathcart MK. Assessment of 5-lipoxygenase involvement in human monocyte-mediated LDL oxidation. J Lipid Res. 1993 Jan;34(1):69-79. PubMed PMID: 8445344.
3: Derian CK, Lewis DF. Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Relationship to the oxidative modification of low density lipoprotein. Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):49-57. PubMed PMID: 1546066.
4: Snyder DW, Cho HL, Gilmore J. Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. Eur J Pharmacol. 1991 Mar 26;195(2):209-15. PubMed PMID: 1651863.
5: Jolly SR, Ordoukhani A, Movahed A. Effect of neuropeptide Y on isolated rat hearts. Pharmacology. 1991;43(3):121-7. PubMed PMID: 1775516.
6: Carnathan GW, Sweeney DM, Travis JJ, Gordon RJ, Sutherland CA, Jariwala N, Clearfield M, O'Rourke S, Huang FC, Van Inwegen RG. The inhibition of 5-lipoxygenase by RG 6866. Agents Actions. 1989 Nov;28(3-4):204-11. PubMed PMID: 2596372.
7: Jolly SR, Travis J, Van Inwegen RG. Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts. Pharmacology. 1989;38(6):352-62. PubMed PMID: 2813496.
