BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 µM, respectively). BI-9564 is useful in further exploring BRD9 bromodomain biology in both in vitro and in vivo settings. Selective inhibitors of bromodomain-containing protein 9 (BRD9) may have therapeutic potential in the treatment of human malignancies and inflammatory diseases.
MedKoo Cat#: 406829
Name: BI-9564
CAS#: 1883429-22-8
Chemical Formula: C20H23N3O3
Exact Mass: 353.1739
Molecular Weight: 353.42
Elemental Analysis: C, 67.97; H, 6.56; N, 11.89; O, 13.58
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
DMF | 5.0 | 14.15 | |
DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.41 | |
DMSO | 5.4 | 15.39 | |
Ethanol | 9.0 | 25.47 |
The following data is based on the product molecular weight 353.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |