Synonym
NOD-IN-1; compound 4; MDK19922; MDK 19922; MDK-19922.
IUPAC/Chemical Name
ethyl 1-tosyl-1H-indole-2-carboxylate
InChi Key
OJMOGUKIYRAILM-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17NO4S/c1-3-23-18(20)17-12-14-6-4-5-7-16(14)19(17)24(21,22)15-10-8-13(2)9-11-15/h4-12H,3H2,1-2H3
SMILES Code
O=C(C(N1S(=O)(C2=CC=C(C)C=C2)=O)=CC3=C1C=CC=C3)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
343.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhao Y, Ye Q, Feng Y, Chen Y, Tan L, Ouyang Z, Zhao J, Hu J, Chen N, Su X,
Dusenge MA, Feng Y, Guo Y. Prevotella genus and its related NOD-like
receptor signaling pathway in young males with stage III periodontitis. Front
Microbiol. 2022 Dec 8;13:1049525. doi: 10.3389/fmicb.2022.1049525. PMID:
36569059; PMCID: PMC9772451.
2: Luo H, Wu X, Xu Z, Hao X, Wang Y, Li M. NOD2/c-Jun NH2-Terminal
Kinase Triggers Mycoplasma ovipneumoniae-Induced Macrophage Autophagy. J
Bacteriol. 2020 Sep 23;202(20):e00689-19. doi: 10.1128/JB.00689-19. PMID:
32778560; PMCID: PMC7515247.
3: Shi CX, Wang Y, Chen Q, Jiao FZ, Pei MH, Gong ZJ. Extracellular Histone H3
Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3
Pathways. Front Cell Infect Microbiol. 2020 May 5;10:196. doi:
10.3389/fcimb.2020.00196. PMID: 32432055; PMCID: PMC7216582.
4: Ou ZL, Wang J, Shi R, Deng J, Liu Y, Luo GX. [Influence of reactive oxygen
species responsive self-assembled nanomicelle loaded with pyroptosis inhibitor
on full-thickness skin defects in diabetic rats]. Zhonghua Shao Shang Yu Chuang
Mian Xiu Fu Za Zhi. 2023 Jan 20;39(1):35-44. Chinese. doi:
10.3760/cma.j.cn501225-20221109-00483. PMID: 36740424; PMCID: PMC11630122.
