MDK-7958, also known as K-Ras(G12C) inhibitor 12, irreversibly binds to and inhibits a common oncogenic mutant, K-Ras(G12C). The last four digits of MDS-7958's CAS registry number are used in its name. MDK-7958 relies on the mutant cysteine for binding and therefore does not affect the wild-type protein.
MedKoo Cat#: 558273
Name: MDK-7958
CAS#: 1469337-95-8
Chemical Formula: C15H17ClIN3O3
Exact Mass: 449.0003
Molecular Weight: 449.67
Elemental Analysis: C, 40.07; H, 3.81; Cl, 7.88; I, 28.22; N, 9.34; O, 10.67
The following data is based on the product molecular weight 449.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
