Synonym
SB-415286; SB 415286; SB415286.
IUPAC/Chemical Name
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
SMILES Code
O=C(C(NC1=CC=C(O)C(Cl)=C1)=C2C3=CC=CC=C3[N+]([O-])=O)NC2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
359.72
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pizarro JG, Folch J, Esparza JL, Jordan J, Pallàs M, Camins A. A molecular
study of pathways involved in the inhibition of cell proliferation in
neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. J Cell Mol
Med. 2009 Sep;13(9B):3906-17. doi: 10.1111/j.1582-4934.2008.00389.x. Epub 2008
Jun 20. PubMed PMID: 18624766; PubMed Central PMCID: PMC4516538.
2: Yeste-Velasco M, Folch J, Jiménez A, Rimbau V, Pallàs M, Camins A. GSK-3 beta
inhibition and prevention of mitochondrial apoptosis inducing factor release are
not involved in the antioxidant properties of SB-415286. Eur J Pharmacol. 2008
Jul 7;588(2-3):239-43. doi: 10.1016/j.ejphar.2008.04.019. Epub 2008 Apr 11.
PubMed PMID: 18502415.
3: Pizarro JG, Yeste-Velasco M, Rimbau V, Casadesús G, Smith MA, Pallàs M, Folch
J, Camins A. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced
cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci. 2008
May-Jun;26(3-4):269-76. doi: 10.1016/j.ijdevneu.2008.02.002. Epub 2008 Feb 8.
PubMed PMID: 18342477.
4: MacAulay K, Hajduch E, Blair AS, Coghlan MP, Smith SA, Hundal HS. Use of
lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the
regulation of glucose transport and glycogen synthase. Eur J Biochem. 2003
Sep;270(18):3829-38. PubMed PMID: 12950267.