Propiverine hydrochloride | CAS#54556-98-8 | CAS#60569-19-9 | Anticholinergic

MedKoo Cat#: 328403 | Name: Propiverine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propiverine hydrochloride, also known as Propiverine and NSC-172140, is a muscarinic cholinergic receptor antagonist used to treat urinary frequency, urgency, and incontinence.

Chemical Structure

Propiverine hydrochloride

CAS#54556-98-8 (HCl); 60569-19-9 (free base)

Theoretical Analysis

MedKoo Cat#: 328403

Name: Propiverine hydrochloride

CAS#: 54556-98-8 (HCl); 60569-19-9 (free base)

Chemical Formula: C24H32ClNO3

Exact Mass:

Molecular Weight: 417.97

Elemental Analysis: C, 68.97; H, 7.72; Cl, 8.48; N, 3.35; O, 11.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Propiverine hydrochloride; Mictonorm; NSC-172140, NSC172140, NSC 172140

IUPAC/Chemical Name

1-methylpiperidin-4-yl 2,2-diphenyl-2-propoxyacetate compound with chloromethane (1:1)

InChi Key

VFHDKVRFMOMYAL-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H29NO3.CH3Cl/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;1-2/h4-13,21H,3,14-18H2,1-2H3;1H3

SMILES Code

O=C(OC1CCN(C)CC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCCC.CCl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 60569-19-9(Propiverine) 54556-98-8(Propiverine Hydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 417.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang W, Zong H, Zhou X, Wang T, Zhang Y. Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis. Indian J Surg. 2015 Dec;77(Suppl 3):1369-77. doi: 10.1007/s12262-015-1264-1. Epub 2015 Apr 4. Review. PubMed PMID: 27011567; PubMed Central PMCID: PMC4775592. 2: Matsui R, Uchida S, Namiki N. Combination effect of physical and gustatory taste masking for propiverine hydrochloride orally disintegrating tablets on palatability. Biol Pharm Bull. 2015;38(1):17-22. doi: 10.1248/bpb.b14-00467. PubMed PMID: 25744453. 3: Sugaya K, Sekiguchi Y, Satoh T, Shiroma K, Kadekawa K, Ashitomi K, Nishijima S. Effect of propiverine hydrochloride on stress urinary incontinence. Int J Urol. 2014 Oct;21(10):1022-5. doi: 10.1111/iju.12513. Epub 2014 Jun 16. PubMed PMID: 24930995. 4: Matsui R, Uchida S, Namiki N. In vitro and in vivo evaluation under finite conditions of a transdermal oil-in-water type emulsified formulation of propiverine hydrochloride. Biol Pharm Bull. 2014;37(10):1661-7. PubMed PMID: 25273389. 5: Leng J, Liao L, Wan B, Du C, Li W, Xie K, Shen Z, Xu Z, Wu S, Fang Z, Ma L, Han S, Feustel C, Yang Y, Madersbacher H. Results of a randomized, double-blind, active-controlled clinical trial with propiverine ER 30 mg in patients with overactive bladder. BJU Int. 2016 Apr 18. doi: 10.1111/bju.13500. [Epub ahead of print] PubMed PMID: 27087507. 6: Kitta T, Tyagi V, Nanri M, Kiniwa M, Nonomura K, Yoshimura N. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr;24(4):683-8. doi: 10.1007/s00192-012-1924-7. Epub 2012 Aug 29. PubMed PMID: 22930215. 7: Kitta T. Editorial comment to effect of propiverine hydrochloride on stress urinary incontinence. Int J Urol. 2014 Oct;21(10):1026. doi: 10.1111/iju.12529. Epub 2014 Jun 22. PubMed PMID: 24954544. 8: Stöhrer M, Mürtz G, Kramer G, Warnack W, Primus G, Jinga V, Manu-Marin A, Calomfirescu N, Strugala G. Efficacy and tolerability of propiverine hydrochloride extended-release compared with immediate-release in patients with neurogenic detrusor overactivity. Spinal Cord. 2013 May;51(5):419-23. doi: 10.1038/sc.2012.174. Epub 2013 Jan 22. PubMed PMID: 23338657. 9: Ogata T, Tanaka D, Ozeki T. Enhancing the solubility and masking the bitter taste of propiverine using crystalline complex formation. Drug Dev Ind Pharm. 2014 Aug;40(8):1084-91. doi: 10.3109/03639045.2013.807280. Epub 2013 Jun 21. PubMed PMID: 23789589. 10: Kadekawa K, Nishijima S, Ashitomi K, Yamamoto H, Sugaya K. Excitatory effect of propiverine hydrochloride on urethral activity in rats. Int J Urol. 2012 Jun;19(6):575-82. doi: 10.1111/j.1442-2042.2012.02977.x. Epub 2012 Feb 29. PubMed PMID: 22376304.