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MedKoo Cat#: 535036 | Name: Propiram

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propiram is used as fumarate in medicine.

Chemical Structure

Propiram
Propiram
CAS#15686-91-6

Theoretical Analysis

MedKoo Cat#: 535036

Name: Propiram

CAS#: 15686-91-6

Chemical Formula: C21H32O4

Exact Mass: 348.2301

Molecular Weight: 348.48

Elemental Analysis: C, 72.38; H, 9.26; O, 18.36

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Propiram
IUPAC/Chemical Name
Pregnane-11,20-dione, 3,21-dihydroxy-, (3-alpha,5-alpha)- (9CI)
InChi Key
XWYBFXIUISNTQG-VKMGZQQJSA-N
InChi Code
InChI=1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-16,19,22-23H,3-11H2,1-2H3/t12-,13+,14-,15-,16+,19+,20-,21-/m0/s1
SMILES Code
C[C@@]1(C2)[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Goa KL, Brogden RN. Propiram. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use as an analgesic. Drugs. 1993 Sep;46(3):428-445. doi: 10.2165/00003495-199346030-00008. PMID: 7693433. 2: Joshi GP. Propiram Shire. IDrugs. 2002 Mar;5(3):281-5. PMID: 15562339. 3: Bloomfield SS, Barden TP, Mitchell J. Propiram and codeine in episiotomy pain. Int J Clin Pharmacol Ther Toxicol. 1981 Apr;19(4):152-7. PMID: 7021431. 4: Sunshine A, Laska EM, Olson NZ, Colon A, Gonzalez L, Tirado S. Analgesic effects of oral propiram fumarate, codeine sulfate and placebo in postoperative pain. Pharmacotherapy. 1983 Sep-Oct;3(5):299-303. doi: 10.1002/j.1875-9114.1983.tb03281.x. PMID: 6359083. 5: Finch JS. Analgesic comparison of propiram fumarate with pentazocine, codeine, and placebo in postsurgical pain. J Clin Pharmacol. 1980 Nov- Dec;20(11):689-92. doi: 10.1002/j.1552-4604.1980.tb01688.x. PMID: 7014656. 6: Korduba CA, Veals J, Radwanski E, Symchowicz S, Chung M. Bioavailability of orally administered propiram fumarate in humans. J Pharm Sci. 1981 May;70(5):521-3. doi: 10.1002/jps.2600700515. PMID: 7241356. 7: Wilson RS, Landers JH. Use of a new oral analgesic, propiram fumarate, in treating postoperative ocular pain. Ann Ophthalmol. 1982 Dec;14(12):1172-4. PMID: 7165237. 8: Desjardins PJ, Cooper SA, Gallegos TL, Allwein JB, Reynolds DC, Kruger GO, Beaver WT. The relative analgesic efficacy of propiram fumarate, codeine, aspirin, and placebo in post-impaction dental pain. J Clin Pharmacol. 1984 Jan;24(1):35-42. doi: 10.1002/j.1552-4604.1984.tb01811.x. PMID: 6368614. 9: Jasinski DR, Martin WR, Hoeldtke R. Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man. Clin Pharmacol Ther. 1971 Jul-Aug;12(4):613-49. doi: 10.1002/cpt1971124613. PMID: 5567808. 10: Kakizawa T, Kawachi H, Yamamoto H, Komiya Y. [Clinical evaluation of Bayer-4503 (propiram fumarate) in oral surgery]. Nihon Koku Geka Gakkai Zasshi. 1972;18(4):456-9. Japanese. doi: 10.5794/jjoms.18.456. PMID: 4511502. 11: Suzuki M, Yusa T, Shima T, Iwatsuki K. [Propiram fumarate, a new analgesic]. Masui. 1971 Sep;20(10):909-11. Japanese. PMID: 4942667. 12: Forrest WH Jr, Brown CR, Shroff PF, Teutsch G. Relative potency of propiram and morphine for analgsia in man. J Clin Pharmacol New Drugs. 1972 Nov- Dec;12(11):440-8. doi: 10.1002/j.1552-4604.1972.tb00244.x. PMID: 4484659. 13: Forrest WH, Brown CR, Katz J, Mahler DL, Shroff PF, Teutsch G, James KE, Brown BW. Combined routes of administration to assay oral analgesia in postoperative pain. J Clin Pharmacol. 1976 Nov-Dec;16(11-12):610-9. doi: 10.1002/j.1552-4604.1976.tb01499.x. PMID: 791972. 14: Bell JA, Shannon HE. Partial agonists of the morphine type: facilitative effects on electrophysiologically recorded C-fiber reflexes in the cat. Neuropharmacology. 1988 Jun;27(6):649-52. doi: 10.1016/0028-3908(88)90188-8. PMID: 2971143. 15: Houde RW. Analgesic effectiveness of the narcotic agonist-antagonists. Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):297S-308S. doi: 10.1111/j.1365-2125.1979.tb04704.x. PMID: 223617; PMCID: PMC1429304. 16: Gilbert PE, Martin WR. The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. J Pharmacol Exp Ther. 1976 Jul;198(1):66-82. PMID: 945350. 17: Jasinski DR. Human pharmacology of narcotic antagonists. Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):287S-290S. doi: 10.1111/j.1365-2125.1979.tb04702.x. PMID: 465291; PMCID: PMC1429310. 18: Young AM, Stephens KR, Hein DW, Woods JH. Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids. J Pharmacol Exp Ther. 1984 Apr;229(1):118-26. PMID: 6142942. 19: Zhou M, Li Y, Liu C, Ma Y, Mi J, Wang S. Simultaneous determination of lappaconitine hydrobromide and isopropiram fumarate in rabbit plasma by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis. 2012 Aug;33(16):2577-83. doi: 10.1002/elps.201100630. PMID: 22899266.