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MedKoo Cat#: 146381 | Name: Tricetin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tricetin is a naturally occurring flavonoid found in certain fruits and flowers, known for its strong antioxidant and anti-inflammatory properties. It works by scavenging free radicals and modulating signaling pathways involved in inflammation and oxidative stress. Tricetin has shown potential in protecting cells from damage, making it of interest in research related to cardiovascular health, neuroprotection, and cancer prevention.

Chemical Structure

Tricetin
Tricetin
CAS#520-31-0

Theoretical Analysis

MedKoo Cat#: 146381

Name: Tricetin

CAS#: 520-31-0

Chemical Formula: C15H10O7

Exact Mass: 302.0427

Molecular Weight: 302.24

Elemental Analysis: C, 59.61; H, 3.34; O, 37.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tricetin;
IUPAC/Chemical Name
5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
InChi Key
ARSRJFRKVXALTF-UHFFFAOYSA-N
InChi Code
1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H
SMILES Code
OC1=CC(O)=C2C(=O)C=C(OC2=C1)C3=CC(O)=C(O)C(O)=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 302.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lin Q, Ding S, Shi M, Cao Y, Liu J, Sun D, Xu W, Pang S, Gu A, Mingyan E. Tricetin attenuates atherosclerosis by suppressing macrophage ferroptosis via activation of the NRF2 pathway. Int Immunopharmacol. 2024 Dec 25;143(Pt 2):113418. doi: 10.1016/j.intimp.2024.113418. Epub 2024 Oct 22. PMID: 39442188. 2: Li W, Lv R, Zou T, Chen M. Tricetin protects against liver fibrosis through promoting autophagy and Nrf2 signaling in hepatic stellate cells. Life Sci. 2024 Aug 15;351:122798. doi: 10.1016/j.lfs.2024.122798. Epub 2024 Jun 7. PMID: 38852802. 3: Sun FF, Hu PF, Xiong Y, Bao JP, Qian J, Wu LD. Tricetin Protects Rat Chondrocytes against IL-1β-Induced Inflammation and Apoptosis. Oxid Med Cell Longev. 2019 Apr 28;2019:4695381. doi: 10.1155/2019/4695381. PMID: 31231454; PMCID: PMC6512055. 4: Chien HW, Chuang CC, Hsieh YH, Lee CY, Yu NY, Yang SF. Tricetin suppresses the cell migration and BMP-6 expression through p38 signaling pathways in human retinal pigment epithelium cells. Environ Toxicol. 2024 Aug;39(8):4148-4155. doi: 10.1002/tox.24294. Epub 2024 Apr 23. PMID: 38654487. 5: Ho HY, Lin FC, Chen PN, Chen MK, Hsin CH, Yang SF, Lin CW. Tricetin Suppresses Migration and Presenilin-1 Expression of Nasopharyngeal Carcinoma through Akt/GSK-3β Pathway. Am J Chin Med. 2020;48(5):1203-1220. doi: 10.1142/S0192415X20500597. PMID: 32668971. 6: Ren J, Yuan L, Wang W, Zhang M, Wang Q, Li S, Zhang L, Hu K. Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Toxicol Appl Pharmacol. 2019 Sep 1;378:114617. doi: 10.1016/j.taap.2019.114617. Epub 2019 Jun 6. PMID: 31176653. 7: Cai L, Zhang X, Hou M, Gao F. Natural flavone tricetin suppresses oxidized LDL-induced endothelial inflammation mediated by Egr-1. Int Immunopharmacol. 2020 Mar;80:106224. doi: 10.1016/j.intimp.2020.106224. Epub 2020 Jan 25. PMID: 31991371. 8: Nagy-Pénzes M, Hajnády Z, Regdon Z, Demény MÁ, Kovács K, El-Hamoly T, Maléth J, Hegyi P, Hegedűs C, Virág L. Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress- Induced DNA Damage Signaling. Biomedicines. 2022 Jun 10;10(6):1371. doi: 10.3390/biomedicines10061371. PMID: 35740393; PMCID: PMC9219693. 9: Wu X, Su D, Xu J, Ge G, Zhang Y, Wu B, Hu K, Ren J, Yang H. Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway. J Agric Food Chem. 2025 Apr 23;73(16):9677-9689. doi: 10.1021/acs.jafc.5c01158. Epub 2025 Apr 14. PMID: 40223750. 10: Chang PY, Hsieh MJ, Hsieh YS, Chen PN, Yang JS, Lo FC, Yang SF, Lu KH. Tricetin inhibits human osteosarcoma cells metastasis by transcriptionally repressing MMP-9 via p38 and Akt pathways. Environ Toxicol. 2017 Aug;32(8):2032-2040. doi: 10.1002/tox.22380. Epub 2016 Nov 8. PMID: 27860196. 11: Wu S, Chang L, Tian L. Identification and Characterization of Two Regiospecific Tricetin UDP-Dependent Glycosyltransferases from Pomegranate (Punica granatum L.). Plants (Basel). 2022 Mar 18;11(6):810. doi: 10.3390/plants11060810. PMID: 35336691; PMCID: PMC8948884. 12: Chung TT, Chuang CY, Teng YH, Hsieh MJ, Lai JC, Chuang YT, Chen MK, Yang SF. Tricetin suppresses human oral cancer cell migration by reducing matrix metalloproteinase-9 expression through the mitogen-activated protein kinase signaling pathway. Environ Toxicol. 2017 Nov;32(11):2392-2399. doi: 10.1002/tox.22452. Epub 2017 Jul 21. PMID: 28731287. 13: Chien MH, Chow JM, Lee WJ, Chen HY, Tan P, Wen YC, Lin YW, Hsiao PC, Yang SF. Tricetin Induces Apoptosis of Human Leukemic HL-60 Cells through a Reactive Oxygen Species-Mediated c-Jun N-Terminal Kinase Activation Pathway. Int J Mol Sci. 2017 Jul 31;18(8):1667. doi: 10.3390/ijms18081667. PMID: 28758971; PMCID: PMC5578057. 14: Chao R, Chow JM, Hsieh YH, Chen CK, Lee WJ, Hsieh FK, Yu NY, Chou MC, Cheng CW, Yang SF, Chien MH. Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1. Expert Opin Ther Targets. 2015;19(10):1293-306. doi: 10.1517/14728222.2015.1075509. Epub 2015 Aug 6. PMID: 26245494. 15: Hsu YL, Uen YH, Chen Y, Liang HL, Kuo PL. Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. J Agric Food Chem. 2009 Sep 23;57(18):8688-95. doi: 10.1021/jf901053x. PMID: 19705844. 16: Hung JY, Chang WA, Tsai YM, Hsu YL, Chiang HH, Chou SH, Huang MS, Kuo PL. Tricetin, a dietary flavonoid, suppresses benzo(a)pyrene‑induced human non‑small cell lung cancer bone metastasis. Int J Oncol. 2015 May;46(5):1985-93. doi: 10.3892/ijo.2015.2915. Epub 2015 Mar 4. PMID: 25738754. 17: Alsamhary K, Al-Enazi N, Alshehri WA, Ameen F. Gold nanoparticles synthesised by flavonoid tricetin as a potential antibacterial nanomedicine to treat respiratory infections causing opportunistic bacterial pathogens. Microb Pathog. 2020 Feb;139:103928. doi: 10.1016/j.micpath.2019.103928. Epub 2019 Dec 13. PMID: 31843547. 18: Hsu YL, Hou MF, Tsai EM, Kuo PL. Tricetin, a dietary flavonoid, induces apoptosis through the reactive oxygen species/c-Jun NH2-terminal kinase pathway in human liver cancer cells. J Agric Food Chem. 2010 Dec 8;58(23):12547-56. doi: 10.1021/jf103159r. Epub 2010 Nov 10. PMID: 21067180. 19: Chobot V, Hadacek F, Bachmann G, Weckwerth W, Kubicova L. In Vitro Evaluation of Pro- and Antioxidant Effects of Flavonoid Tricetin in Comparison to Myricetin. Molecules. 2020 Dec 11;25(24):5850. doi: 10.3390/molecules25245850. PMID: 33322312; PMCID: PMC7768484. 20: Marin PD, Grayer RJ, Grujic-Jovanovic S, Kite GC, Veitch NC. Glycosides of tricetin methyl ethers as chemosystematic markers in Stachys subgenus Betonica. Phytochemistry. 2004 May;65(9):1247-53. doi: 10.1016/j.phytochem.2004.04.014. PMID: 15184009.