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MedKoo Cat#: 326916 | Name: Losigamone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Losigamone, also known as AO-33; ADD-137022, is GABA receptor agonist potentially for the treatment of partial seizures.

Chemical Structure

Losigamone
Losigamone
CAS#112856-44-7

Theoretical Analysis

MedKoo Cat#: 326916

Name: Losigamone

CAS#: 112856-44-7

Chemical Formula: C12H11ClO4

Exact Mass: 254.0346

Molecular Weight: 254.67

Elemental Analysis: C, 56.60; H, 4.35; Cl, 13.92; O, 25.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AO-33; AO 33; AO33; ADD-137022; ADD 137022; ADD137022; Losigamone
IUPAC/Chemical Name
(5R*)-5-((alphaS*)-o-Chloro-alpha-hydroxybenzyl)-4-methoxy-2(5H)-furanone
InChi Key
ICDNYWJQGWNLFP-RYUDHWBXSA-N
InChi Code
InChI=1S/C12H11ClO4/c1-16-9-6-10(14)17-12(9)11(15)7-4-2-3-5-8(7)13/h2-6,11-12,15H,1H3/t11-,12-/m0/s1
SMILES Code
O=C1O[C@H]([C@@H](O)C2=CC=CC=C2Cl)C(OC)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Willmore LJ. Losigamone. Dr Willmar Schwabe. Curr Opin Investig Drugs. 2001 Dec;2(12):1763-6. Review. PubMed PMID: 11892943. 2: Perucca E, Bialer M. The clinical pharmacokinetics of the newer antiepileptic drugs. Focus on topiramate, zonisamide and tiagabine. Clin Pharmacokinet. 1996 Jul;31(1):29-46. Review. PubMed PMID: 8827398. 3: Biber A, Dienel A. Pharmacokinetics of losigamone, a new antiepileptic drug, in healthy male volunteers. Int J Clin Pharmacol Ther. 1996 Jan;34(1):6-11. PubMed PMID: 8688997. 4: Dimpfel W, Chatterjee SS, Nöldner M, Ticku MK. Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system. Epilepsia. 1995 Oct;36(10):983-9. PubMed PMID: 7555962.