MedKoo Cat#: 562142 | Name: MPT0B002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MPT0B002 is a microtubule inhibitor. It acts by downregulating T315I mutant Bcr-Abl and inducing apoptosis of imatinib-resistant chronic myeloid leukemia cell.

Chemical Structure

MPT0B002
MPT0B002
CAS#946077-08-3

Theoretical Analysis

MedKoo Cat#: 562142

Name: MPT0B002

CAS#: 946077-08-3

Chemical Formula: C19H19NO4

Exact Mass: 325.1314

Molecular Weight: 325.36

Elemental Analysis: C, 70.14; H, 5.89; N, 4.31; O, 19.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
MPT0B002; MPT-0-B-002; MPT 0 B 002;
IUPAC/Chemical Name
(1-Methyl-1H-indol-5-yl)-(3,4,5-trimethoxy-phenyl)-methanone
InChi Key
ZACNDXXBCBNGMV-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19NO4/c1-20-8-7-12-9-13(5-6-15(12)20)18(21)14-10-16(22-2)19(24-4)17(11-14)23-3/h5-11H,1-4H3
SMILES Code
O=C(C1=CC2=C(N(C)C=C2)C=C1)C3=CC(OC)=C(OC)C(OC)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yeh YY, Liou JP, Lee YL, Lin JY, Huang HM. MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells. Invest New Drugs. 2017 Aug;35(4):427-435. doi: 10.1007/s10637-017-0457-9. Epub 2017 Mar 27. PubMed PMID: 28349229.