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MedKoo Cat#: 525970 | Name: PF-4778574
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.

Chemical Structure

PF-4778574
PF-4778574
CAS#1219633-99-4

Theoretical Analysis

MedKoo Cat#: 525970

Name: PF-4778574

CAS#: 1219633-99-4

Chemical Formula: C19H22N2O3S2

Exact Mass: 390.1072

Molecular Weight: 390.52

Elemental Analysis: C, 58.44; H, 5.68; N, 7.17; O, 12.29; S, 16.42

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
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Related CAS #
No Data
Synonym
PF-4778574; PF 4778574; PF4778574; PF-44462786; PF 44462786; PF44462786;
IUPAC/Chemical Name
2-Propanesulfonamide, N-((3R,4S)-3-(4-(5-cyano-2-thienyl)phenyl)tetrahydro-2H-pyran-4-yl)-
InChi Key
FFAGHPLLBXWCSF-MSOLQXFVSA-N
InChi Code
InChI=1S/C19H22N2O3S2/c1-13(2)26(22,23)21-18-9-10-24-12-17(18)14-3-5-15(6-4-14)19-8-7-16(11-20)25-19/h3-8,13,17-18,21H,9-10,12H2,1-2H3/t17-,18+/m1/s1
SMILES Code
CC(S(=O)(N[C@@H]1[C@@H](C2=CC=C(C3=CC=C(C#N)S3)C=C2)COCC1)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 390.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Guo L, Wang S, Tian H, Shang M, Xu J, Wang C. Novel synergistic treatment for depression: involvement of GSK3β-regulated AMPA receptors in the prefrontal cortex of mice. Cereb Cortex. 2023 Oct 9;33(20):10504-10513. doi: 10.1093/cercor/bhad299. PMID: 37566915. 2: Ma X, Li L, Li Z, Huang Z, Yang Y, Liu P, Guo D, Li Y, Wu T, Luo R, Xu J, Ye WC, Jiang B, Shi L. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. EMBO Rep. 2022 Oct 6;23(10):e54543. doi: 10.15252/embr.202154543. Epub 2022 Aug 22. PMID: 35993189; PMCID: PMC9535807. 3: Jabarin R, Levy N, Abergel Y, Berman JH, Zag A, Netser S, Levy AP, Wagner S. Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation. Transl Psychiatry. 2021 Apr 22;11(1):234. doi: 10.1038/s41398-021-01347-1. PMID: 33888678; PMCID: PMC8062516. 4: Shen M, Lv D, Li S, Zhang Y, Wang Z, Zhao C, Chen X, Wang C. Positive Allosteric Modulation of AMPAR by PF-4778574 Produced Rapid Onset Antidepressant Actions in Mice. Cereb Cortex. 2019 Sep 13;29(10):4438-4451. doi: 10.1093/cercor/bhy324. PMID: 30566581. 5: Shaffer CL, Hurst RS, Scialis RJ, Osgood SM, Bryce DK, Hoffmann WE, Lazzaro JT, Hanks AN, Lotarski S, Weber ML, Liu J, Menniti FS, Schmidt CJ, Hajós M. Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574. J Pharmacol Exp Ther. 2013 Oct;347(1):212-24. doi: 10.1124/jpet.113.204735. Epub 2013 Jul 30. PMID: 23899905. 6: Doran AC, Osgood SM, Mancuso JY, Shaffer CL. An evaluation of using rat- derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations. Drug Metab Dispos. 2012 Nov;40(11):2162-73. doi: 10.1124/dmd.112.046391. Epub 2012 Aug 16. PMID: 22899853. 7: Macauley D. American Chemical Society-239th national meeting--Investigating new therapeutic candidates: part 1. 21-25 March 2010, San Francisco, CA, USA. IDrugs. 2010 May;13(5):289-91. PMID: 20432180. 8: Roberts BM, Holden DE, Shaffer CL, Seymour PA, Menniti FS, Schmidt CJ, Williams GV, Castner SA. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav Brain Res. 2010 Sep 1;212(1):41-8. doi: 10.1016/j.bbr.2010.03.039. Epub 2010 Mar 27. PMID: 20347881.

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