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MedKoo Cat#: 525914 | Name: Periciazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Periciazine is a drug that belongs to the phenothiazine class of typical antipsychotics. Periciazine is used to treat short-term severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia.

Chemical Structure

Periciazine
CAS#2622-26-6

Theoretical Analysis

MedKoo Cat#: 525914

Name: Periciazine

CAS#: 2622-26-6

Chemical Formula: C21H23N3OS

Exact Mass: 365.1562

Molecular Weight: 365.50

Elemental Analysis: C, 69.01; H, 6.34; N, 11.50; O, 4.38; S, 8.77

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 550.00 2 Weeks
100mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
Periciazine; Periciazine; Periciazinum; RP 8908; RP 8909; SKF 20,716.
IUPAC/Chemical Name
10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
InChi Key
LUALIOATIOESLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
SMILES Code
c1ccc2c(c1)N(c3cc(ccc3S2)C#N)CCCN4CCC(CC4)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Pericyazine is a selective D2-dopamine receptor antagonist.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 127.5 348.84
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 365.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(10):65-71. Russian. doi: 10.17116/jnevro201711710165-71. PMID: 29171491. 11: Juliano ACDSRS, Lucchetti ALG, Silva JTSD, Santos LG, Nunes JBT, Fernandes GC, Lucchetti G. Inappropriate Prescribing in Older Hospitalized Adults: A Comparison of Medical Specialties. J Am Geriatr Soc. 2018 Feb;66(2):383-388. doi: 10.1111/jgs.15138. Epub 2017 Oct 4. PMID: 28975608. 12: Danilov DS. Sovremennyĭ vzgliad na istoriiu atipichnykh antipsikhoticheskikh sredstv [A current view on the history of atypical antipsychotics]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(5):85-93. Russian. doi: 10.17116/jnevro20171175185-93. PMID: 28638038. 13: Cai HL, Deng Y, Fang PF, Cao S, Hou ZY, Wu YQ, Chen XJ, Yan M, Zhang B. A sensitive LC-MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers. J Pharm Biomed Anal. 2017 Feb 20;135:67-74. doi: 10.1016/j.jpba.2016.12.007. Epub 2016 Dec 15. PMID: 28012307. 14: Matar HE, Almerie MQ, Makhoul S, Xia J, Humphreys P. Pericyazine for schizophrenia. Cochrane Database Syst Rev. 2014 May 13;2014(5):CD007479. doi: 10.1002/14651858.CD007479.pub2. PMID: 24825770; PMCID: PMC11023599. 15: Avgerinos D, Rabitnokov Y, Worku B, Neragi-Miandoab S, Girardi LN. Fifteen- year experience and outcomes of pericardiectomy for constrictive pericarditis. J Card Surg. 2014 Jul;29(4):434-8. doi: 10.1111/jocs.12344. Epub 2014 Apr 18. PMID: 24750218. 16: Futsukaichi K, Matsumoto K, Fujita K, Abe R, Noguchi T. [Severe hypotension and ventricular fibrillation during combined general and epidural anesthesia in a patient on major tranquilizers]. Masui. 2012 Oct;61(10):1121-4. Japanese. PMID: 23157101. 17: Ikeda H, Tsuji E, Matsubara T, Yukawa M, Fujisawa M, Yukawa E, Aki H. Incompatibility between propericiazine oral solution and tea-based drink. Chem Pharm Bull (Tokyo). 2012;60(9):1207-11. doi: 10.1248/cpb.c12-00116. PMID: 22976331. 18: Hong PS, Veasey RA, Sulke N. All is not lost: utilizing continuous remote ILR monitoring to diagnose syncope. Pacing Clin Electrophysiol. 2010 Jun 1;33(6):763-5. doi: 10.1111/j.1540-8159.2009.02662.x. Epub 2010 Feb 1. PMID: 20132509. 19: McGregor C, Srisurapanont M, Mitchell A, Wickes W, White JM. Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. J Subst Abuse Treat. 2008 Oct;35(3):334-42. doi: 10.1016/j.jsat.2007.12.003. Epub 2008 Mar 7. PMID: 18329221. 20: Kandagal PB, Kalanur SS, Manjunatha DH, Seetharamappa J. Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods. J Pharm Biomed Anal. 2008 Jun 9;47(2):260-7. doi: 10.1016/j.jpba.2008.01.027. Epub 2008 Jan 20. PMID: 18313253.