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MedKoo Cat#: 525580 | Name: LY-368975

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. It is capable of reducing food consumption in rodents. Compounds of this class may have use in the treatment of obesity and eating disorders.

Chemical Structure

LY-368975
LY-368975
CAS#163059-33-4 (R-isomer)

Theoretical Analysis

MedKoo Cat#: 525580

Name: LY-368975

CAS#: 163059-33-4 (R-isomer)

Chemical Formula: C17H21NOS

Exact Mass: 287.1344

Molecular Weight: 287.42

Elemental Analysis: C, 71.04; H, 7.36; N, 4.87; O, 5.57; S, 11.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
53179-07-0 (free base) 57754-86-6 (HCl) 163059-33-4 (R-isomer)
Synonym
LY-368975; LY 368975; LY368975; (R)-Thionisoxetine; (R)-Nisoxetine;
IUPAC/Chemical Name
Benzenepropanamine, N-methyl-gamma-(2-(methylthio)phenoxy)-, (gammaR)-
InChi Key
NDVZIUGCCMZHLG-HNNXBMFYSA-N
InChi Code
InChI=1S/C17H21NOS/c1-18-13-12-15(14-8-4-3-5-9-14)19-16-10-6-7-11-17(16)20-2/h3-11,15,18H,12-13H2,1-2H3/t15-/m0/s1
SMILES Code
CNCC[C@@H](c1ccccc1)Oc2ccccc2SC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 287.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Filannino MA, Matarrese M, Turolla EA, Masiello V, Moresco RM, Todde S, Verza E, Magni F, Cattaneo A, Bachi A, Kienle MG, Fazio F. Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography. Appl Radiat Isot. 2007 Nov;65(11):1232-9. Epub 2007 Jun 26. PubMed PMID: 17646106. 2: Jones CK, Eastwood BJ, Need AB, Shannon HE. Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology. 2006 Dec;51(7-8):1172-80. Epub 2006 Oct 11. PubMed PMID: 17045620. 3: Iyengar S, Webster AA, Hemrick-Luecke SK, Xu JY, Simmons RM. Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. J Pharmacol Exp Ther. 2004 Nov;311(2):576-84. Epub 2004 Jul 13. PubMed PMID: 15254142. 4: Katofiasc MA, Nissen J, Audia JE, Thor KB. Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats. Life Sci. 2002 Aug 2;71(11):1227-36. PubMed PMID: 12106588. 5: Rowland NE, Lo J, Robertson K. Acute anorectic effect of single and combined drugs in mice using a non-deprivation protocol. Psychopharmacology (Berl). 2001 Sep;157(2):193-6. PubMed PMID: 11594445. 6: Rowland NE, Marshall M, Robertson K. Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine. Eur J Pharmacol. 2001 May 4;419(1):61-4. PubMed PMID: 11348631. 7: Rowland NE, Marshall M, Roth JD. Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats. Psychopharmacology (Berl). 2000 Mar;149(1):77-83. PubMed PMID: 10789886. 8: Gehlert DR, Dreshfield L, Tinsley F, Benvenga MJ, Gleason S, Fuller RW, Wong DT, Hemrick-Luecke SK. The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding. J Pharmacol Exp Ther. 1998 Oct;287(1):122-7. PubMed PMID: 9765330. 9: Gehlert DR, Hemrick-Luecke SK, Schober DA, Krushinski J, Howbert JJ, Robertson DW, Wong DT, Fuller RW. (R)-thionisoxetine, a potent and selective inhibitor of central and peripheral norepinephrine uptake. Life Sci. 1995;56(22):1915-20. PubMed PMID: 7746100.