Synonym
EGIS-9377; EGIS9377; EGIS 9377;
IUPAC/Chemical Name
2-(methylthio)-N-(2-morpholinoethyl)-8,9-dihydro-7H-thiopyrano[3,2-d][1,2,4]triazolo[1,5-a]pyrimidin-5-amine
InChi Key
JWILWRZDFKYGPJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H22N6OS2/c1-23-15-18-14-17-11-3-2-10-24-12(11)13(21(14)19-15)16-4-5-20-6-8-22-9-7-20/h16H,2-10H2,1H3
SMILES Code
CSc(n1)nn2c1nc(CCCS3)c3c2NCCN4CCOCC4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
366.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ishitani T, Hattori Y, Sakuraya F, Onozuka H, Makino T, Matsuda N, Gando S, Kemmotsu O. Effects of Ca2+ sensitizers on contraction, [Ca2+]i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: potential usefulness as inotropic agents. J Pharmacol Exp Ther. 2001 Aug;298(2):613-22. PMID: 11454923.
2: Fukutomi T, Satoh K, Ogoshi S, Ichihara K. Effects of pimobendan and EGIS 9377, cardiotonic agents, and OG-VI, a nucleoside-nucleotide mixture, administered during reperfusion after ischemia on stunned myocardium in dogs. Coron Artery Dis. 2000 Feb;11(1):83-90. doi: 10.1097/00019501-200002000-00014. PMID: 10715811.
3: Hattori Y, Ishitani T, Tomita F, Gando S, Yokoshiki H, Azuma M, Kemmotsu O, Kanno M. Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity. Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):585-90. doi: 10.1007/s002109900127. PMID: 10598798.
