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MedKoo Cat#: 526838 | Name: RH01687
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RH01687 is a potent β-cell protector. RH01687 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.

Chemical Structure

RH01687
RH01687
CAS#302901-13-9

Theoretical Analysis

MedKoo Cat#: 526838

Name: RH01687

CAS#: 302901-13-9

Chemical Formula: C12H9ClN6O2S

Exact Mass: 336.0196

Molecular Weight: 336.75

Elemental Analysis: C, 42.80; H, 2.69; Cl, 10.53; N, 24.96; O, 9.50; S, 9.52

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,150.00 2 Weeks
200mg USD 1,850.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,850.00 2 Weeks
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Related CAS #
No Data
Synonym
RH01687; RH-01687; RH 01687.
IUPAC/Chemical Name
3-(4-Chloro-2-nitro-5-pyrrol-1-ylphenyl)sulfanyl-1H-1,2,4-triazol-5-amine
InChi Key
BOVTVNWNYFQVMI-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H9ClN6O2S/c13-7-5-9(19(20)21)10(22-12-15-11(14)16-17-12)6-8(7)18-3-1-2-4-18/h1-6H,(H3,14,15,16,17)
SMILES Code
NC1=NC(SC2=CC(N3C=CC=C3)=C(Cl)C=C2[N+]([O-])=O)=NN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
RH01687 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.
In vitro activity:
This study shows that the compounds tested promote β cell survival by reducing the expression of key genes of the unfolded protein response and apoptosis, thus alleviating ER stress. Identification of small molecules that prevent ER stress-induced β cell dysfunction and death may provide a new modality for the treatment of diabetes. Reference: ACS Chem Biol. 2014 Dec 19;9(12):2796-806. http://www.probechem.com/products_RH01687.html
In vivo activity:
To be determined
Solvent mg/mL mM
Solubility
DMSO 67.0 198.95
Ethanol 5.0 14.85
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 336.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19;9(12):2796-806. doi: 10.1021/cb500740d. Epub 2014 Oct 16. PMID: 25279668; PMCID: PMC4273981.
In vitro protocol:
1. Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19;9(12):2796-806. doi: 10.1021/cb500740d. Epub 2014 Oct 16. PMID: 25279668; PMCID: PMC4273981.
In vivo protocol:
To be determined
Tran, K., Li, Y., Duan, H., Arora, D., Lim, H. Y., & Wang, W. (2014). Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS chemical biology, 9(12), 2796-2806. Duan, H., Lee, J. W., Moon, S. W., Arora, D., Li, Y., Lim, H. Y., & Wang, W. (2016). Discovery, synthesis, and evaluation of 2, 4-diaminoquinazolines as a novel class of pancreatic β-cell-protective agents against endoplasmic reticulum (ER) stress. Journal of medicinal chemistry, 59(17), 7783-7800. NARAYANAN, R., BOYLE, L. D., NG, S., KAHLON, A., CROSS, A., DING, C., ... & MALIK, H. Z. Insulin Secretion. Tsang, A. H., Barclay, J. L., & Oster, H. (2014). Interactions between endocrine and circadian systems. Journal of molecular endocrinology, 52(1), R1-R16.