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MedKoo Cat#: 597963 | Name: Emd 51921

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Emd 51921 is a linear renin-inhibiting peptide.

Chemical Structure

Emd 51921
Emd 51921
CAS#133928-36-6

Theoretical Analysis

MedKoo Cat#: 597963

Name: Emd 51921

CAS#: 133928-36-6

Chemical Formula: C39H58T2N8O7

Exact Mass: 756.4749

Molecular Weight: 756.97

Elemental Analysis: C, 61.88; H, 8.52; N, 14.80; O, 14.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Emd 51921; Emd-51921; Emd51921; Emd 51 921; Emd 51,921; Emd-51,921; Emd51,921;
IUPAC/Chemical Name
tert-butyl ((4S,8S,9R,15R)-1-(6-amino-2-methylpyrimidin-4-yl)-4-((R)-sec-butyl)-9-(cyclohexylmethyl)-8-hydroxy-3,6,11,14-tetraoxo-16-(phenyl-2,6-t2)-2,5,10,13-tetraazahexadecan-15-yl)carbamate
InChi Key
JEBBUBZRWRTEIC-DXJZLVBHSA-N
InChi Code
InChI=1S/C39H60N8O7/c1-7-24(2)35(37(52)41-22-28-20-32(40)44-25(3)43-28)47-33(49)21-31(48)29(18-26-14-10-8-11-15-26)45-34(50)23-42-36(51)30(19-27-16-12-9-13-17-27)46-38(53)54-39(4,5)6/h9,12-13,16-17,20,24,26,29-31,35,48H,7-8,10-11,14-15,18-19,21-23H2,1-6H3,(H,41,52)(H,42,51)(H,45,50)(H,46,53)(H,47,49)(H2,40,43,44)/t24-,29-,30-,31+,35+/m1/s1/i16T,17T
SMILES Code
O=C(CNC([C@H](NC(OC(C)(C)C)=O)Cc1c([3H])cccc1[3H])=O)N[C@@H]([C@H](CC(N[C@H](C(NCc2cc(N)nc(C)n2)=O)[C@H](C)CC)=O)O)CC3CCCCC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 756.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ziegler K, Kolac C, Ising W. ATP-dependent transport of the linear renin-inhibiting peptide EMD 51921 by canalicular plasma membrane vesicles of rat liver: evidence of drug-stimulatable ATP-hydrolysis. Biochim Biophys Acta. 1994 Dec 30;1196(2):209-17. PubMed PMID: 7841185. 2: Ziegler K, Sänger U. Binding proteins for linear renin-inhibiting peptides in basolateral plasma membranes of rat liver. Biochim Biophys Acta. 1992 Jan 31;1103(2):219-28. PubMed PMID: 1543706. 3: Katz SA, Malvin RL, Lee J, Kim SH, Murray RD, Opsahl JA, Abraham PA. Analysis of active renin heterogeneity. Proc Soc Exp Biol Med. 1991 Sep;197(4):387-92. PubMed PMID: 1908097. 4: Kim RB, Perry PR, Wilkinson GR. High affinity uptake by isolated rat hepatocytes of a linear pseudo-hexapeptide, ditekiren. Biochim Biophys Acta. 1997 Aug 14;1328(1):41-7. PubMed PMID: 9298943.