Fosifloxuridine nafalbenamide, also known as NUC-3373, is a potent cancel stem cell inhibitor. NUC-3373 has preferential cytotoxic effects on leukemic stem cells (LSCs). In vitro data confirmed that NUC-3373 exerts its cytotoxic activity independently of thymidine kinase in TK-deficient tumor cell lines, and it is resistant to degradative action by catabolic enzymes including TP and DPD.19 In addition, NUC-3373 was found to generate 366- fold higher intracellular levels of the active monophosphate form, FdUMP, in the human colorectal cancer cell line HT29 compared with 5-FU and achieved significantly greater tumor volume reduction than 5-FU in HT29 xenograft studies.
MedKoo Cat#: 596786
Name: Fosifloxuridine nafalbenamide
CAS#: 1332837-31-6
Chemical Formula: C29H30F2N4O8P
Exact Mass: 631.1769
Molecular Weight: 631.54
Elemental Analysis: C, 55.15; H, 4.79; F, 6.02; N, 8.87; O, 20.27; P, 4.90
The following data is based on the product molecular weight 631.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
