LY 302148 | CAS#182564-47-2 | 5-HT1F receptor agonist

MedKoo Cat#: 525541 | Name: LY 302148

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 302148 is a 5-HT1F receptor agonist that inhibits neurogenic dural inflammation in guinea pigs. LY 302148 has potential for migraine therapeutics.

Chemical Structure

LY 302148

CAS#182564-47-2

Theoretical Analysis

MedKoo Cat#: 525541

Name: LY 302148

CAS#: 182564-47-2

Chemical Formula: C19H23FN4

Exact Mass: 326.1907

Molecular Weight: 326.42

Elemental Analysis: C, 69.91; H, 7.10; F, 5.82; N, 17.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LY 302148; LY-302148; LY302148.

IUPAC/Chemical Name

1H-Indole, 5-fluoro-3-(1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-4-piperidinyl)-

InChi Key

RFIDURCIAHBFRJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H23FN4/c1-23-13-14(11-22-23)4-7-24-8-5-15(6-9-24)18-12-21-19-3-2-16(20)10-17(18)19/h2-3,10-13,15,21H,4-9H2,1H3

SMILES Code

CN1N=CC(CCN2CCC(C3=CNC4=C3C=C(F)C=C4)CC2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Johnson KW, Schaus JM, Durkin MM, Audia JE, Kaldor SW, Flaugh ME, Adham N, Zgombick JM, Cohen ML, Branchek TA, Phebus LA. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport. 1997 Jul 7;8(9-10):2237-40. PubMed PMID: 9243618.