MedKoo Cat#: 525840 | Name: PD 132002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 132002 is a renin inhibitor. Studies with PD 132002 show that the dissociation sometimes observed in studies with renin inhibitors between changes in BP (blood pressure) and PRA (plasma renin activity) may be attributed to the assay used to determine PRA.

Chemical Structure

PD 132002
PD 132002
CAS#134452-04-3

Theoretical Analysis

MedKoo Cat#: 525840

Name: PD 132002

CAS#: 134452-04-3

Chemical Formula: C31H50N4O9S

Exact Mass: 654.3298

Molecular Weight: 654.82

Elemental Analysis: C, 56.86; H, 7.70; N, 8.56; O, 21.99; S, 4.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PD-132002; PD132002; PD 132002
IUPAC/Chemical Name
(2R)-methyl 3-amino-2-((2S)-N-((2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)-3-oxopropanoate
InChi Key
DUBBEKGYCZQJMR-QSKQZBQPSA-N
InChi Code
InChI=1S/C31H50N4O9S/c1-21(2)18-26(36)28(37)25(20-23-12-8-5-9-13-23)35(27(29(32)38)31(40)43-3)30(39)24(19-22-10-6-4-7-11-22)33-45(41,42)34-14-16-44-17-15-34/h4,6-7,10-11,21,23-28,33,36-37H,5,8-9,12-20H2,1-3H3,(H2,32,38)/t24-,25-,26-,27+,28?/m0/s1
SMILES Code
O=C(N)[C@H](C(OC)=O)N(C([C@H](CC1=CC=CC=C1)NS(=O)(N2CCOCC2)=O)=O)[C@@H](CC3CCCCC3)C(O)[C@@H](O)CC(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 654.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Palmer RK, Rapundalo ST, Batley BL, Barnes AE, Singh S, Ryan MJ, Taylor DG Jr. Disparity between blood pressure and PRA inhibition after administration of a renin inhibitor to anesthetized dogs: methodological considerations. Clin Exp Hypertens. 1993 Jul;15(4):663-81. PubMed PMID: 8374609. 2: Repine JT, Himmelsbach RJ, Hodges JC, Kaltenbronn JS, Sircar I, Skeean RW, Brennan ST, Hurley TR, Lunney E, Humblet CC, et al. Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. J Med Chem. 1991 Jul;34(7):1935-43. PubMed PMID: 2066966.