MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 525075 | Name: Fosfluconazole
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fosfluconazole is water-soluble phosphate prodrug of fluconazole. Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

Chemical Structure

Fosfluconazole
Fosfluconazole
CAS#194798-83-9 (free acid)

Theoretical Analysis

MedKoo Cat#: 525075

Name: Fosfluconazole

CAS#: 194798-83-9 (free acid)

Chemical Formula: C13H13F2N6O4P

Exact Mass: 386.0704

Molecular Weight: 386.25

Elemental Analysis: C, 40.42; H, 3.39; F, 9.84; N, 21.76; O, 16.57; P, 8.02

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
194798-85-1 (sodium) 194798-83-9 (free acid)
Synonym
Fosfluconazole; Fosfluconazole; Procif; Prodif; Fosfluconazol; UK 292663; UK292663; UK-292663; UK-292,663
IUPAC/Chemical Name
1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-((1H-1,2,4-triazol-1-yl)methyl)ethyl dihydrogen phosphate
InChi Key
GHJWNRRCRIGGIO-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)
SMILES Code
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)OP(=O)(O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hagiya H, Kajioka H. Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of fosfluconazole and micafungin. Intern Med. 2013;52(18):2139-43. PubMed PMID: 24042529. 2: Aoyama T, Hirata K, Hirata R, Yamazaki H, Yamamoto Y, Hayashi H, Matsumoto Y. Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients. J Clin Pharm Ther. 2012 Jun;37(3):356-63. doi: 10.1111/j.1365-2710.2011.01297.x. Epub 2011 Aug 24. PubMed PMID: 21883330. 3: Sawada A, Sakata N, Higuchi B, Takeshita Y, Ishihara T, Sakata A, Kouroki M, Kondo O, Koyama M, Hirano S, Yasui M, Inoue M, Yoshioka A, Kawa K. [Comparison of micafungin and fosfluconazole as prophylaxis for invasive fungal infection during neutropenia in children undergoing chemotherapy and hematopoietic stem cell transplantation]. Rinsho Ketsueki. 2009 Dec;50(12):1692-9. Japanese. PubMed PMID: 20068276. 4: Takahashi D, Nakamura T, Shigematsu R, Matsui M, Araki S, Kubo K, Sato H, Shirahata A. Fosfluconazole for antifungal prophylaxis in very low birth weight infants. Int J Pediatr. 2009;2009:274768. doi: 10.1155/2009/274768. Epub 2009 Apr 23. PubMed PMID: 19946419; PubMed Central PMCID: PMC2778452. 5: Aoyama T, Ogata K, Shimizu M, Hatta S, Masuhara K, Shima Y, Kimura K, Matsumoto Y. Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats. Drug Metab Pharmacokinet. 2005 Dec;20(6):485-90. PubMed PMID: 16415533. 6: Sobue S, Tan K, Haug-Pihale G. The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. Br J Clin Pharmacol. 2005 Feb;59(2):160-6. PubMed PMID: 15676037; PubMed Central PMCID: PMC1884746. 7: Kawakami Y, Nagino K, Shinkai K, Sobue S, Abe M, Ishiko J. [Nonclinical studies and clinical studies on fosfluconazole, a triazole antifungal agent (Prodif)]. Nihon Yakurigaku Zasshi. 2004 Jul;124(1):41-51. Review. Japanese. PubMed PMID: 15226621. 8: Sobue S, Tan K, Layton G, Eve M, Sanderson JB. Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers. Br J Clin Pharmacol. 2004 Jul;58(1):20-5. PubMed PMID: 15206988; PubMed Central PMCID: PMC1884549. 9: Sobue S, Tan K, Layton G, Leclerc V, Weil A. The effects of renal impairment on the pharmacokinetics and safety of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. Br J Clin Pharmacol. 2004 Jun;57(6):773-84. PubMed PMID: 15151523; PubMed Central PMCID: PMC1884522. 10: Sobue S, Tan K, Shaw L, Layton G, Hust R. Comparison of the pharmacokinetics of fosfluconazole and fluconazole after single intravenous administration of fosfluconazole in healthy Japanese and Caucasian volunteers. Eur J Clin Pharmacol. 2004 Jun;60(4):247-53. Epub 2004 Apr 22. PubMed PMID: 15103438. 11: Sobue S, Sekiguchi K, Shimatani K, Tan K. Pharmacokinetics and safety of Fosfluconazole after single intravenous bolus injection in healthy male Japanese volunteers. J Clin Pharmacol. 2004 Mar;44(3):284-92. PubMed PMID: 14973307.

View History

Fosdagrocorat

Fosdagrocorat

CVT-2513

CVT-2513

Onternabez

Onternabez

HP 228

HP 228

Napavin

Napavin

Vincoline

Vincoline