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MedKoo Cat#: 525045 | Name: Fenoterol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenoterol hydrochloride is a β2 adrenoreceptor agonist designed to open up the airways to the lungs. It is classed as sympathomimetic β2 agonist and asthma medication.

Chemical Structure

Fenoterol hydrochloride
Fenoterol hydrochloride
CAS#1944-10-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 525045

Name: Fenoterol hydrochloride

CAS#: 1944-10-1 (HCl)

Chemical Formula: C17H22ClNO4

Exact Mass: 0.0000

Molecular Weight: 339.81

Elemental Analysis: C, 60.09; H, 6.53; Cl, 10.43; N, 4.12; O, 18.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1944-10-1 (HCl) 1944-12-3 (HBr) 13392-18-2 (free base) 130156-24-0 (RS isomer) 36369-23-0 (RS isomer HBr)
Synonym
Fenoterol hydrochloride; Fenoterol HCl; TH-1179 HCl; TH1179 HCl; TH 1179 HCl; NSC-292265; NSC292265; NSC 292265;
IUPAC/Chemical Name
(1RS)-1-(3,5-Dihydroxyphenyl)-2-(((1RS)-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethanol hydrochloride
InChi Key
HNINVRLEFUPHLU-NRNQBQMASA-N
InChi Code
InChI=1S/C17H21NO4.ClH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H/t11-,17+;/m1./s1
SMILES Code
CC(NCC(O)C1=CC(O)=CC(O)=C1)CC2=CC=C(O)C=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 26971030. 4: Alves E, Lukoyanov N, Serrão P, Moura D, Moreira-Rodrigues M. Epinephrine increases contextual learning through activation of peripheral β2-adrenoceptors. Psychopharmacology (Berl). 2016 Jun;233(11):2099-108. doi: 10.1007/s00213-016-4254-5. Epub 2016 Mar 2. PubMed PMID: 26935825. 5: Yamasmit W, Chaithongwongwatthana S, Tolosa JE, Limpongsanurak S, Pereira L, Lumbiganon P. Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy. Cochrane Database Syst Rev. 2015 Dec 8;(12):CD004733. doi: 10.1002/14651858.CD004733.pub4. Review. PubMed PMID: 26645888. 6: Miraglia Del Giudice M, Campana G, Galdo F, De Vivo D, Cuppari C, Coronella A, Maiello N. β2-AGONISTS IN CHILDHOOD ASTHMA. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2 Suppl 1):137-41. PubMed PMID: 26634602. 7: Cannavo A, Liccardo D, Lymperopoulos A, Gambino G, D'Amico ML, Rengo F, Koch WJ, Leosco D, Ferrara N, Rengo G. β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia. J Pharmacol Exp Ther. 2016 Feb;356(2):503-13. doi: 10.1124/jpet.115.228411. Epub 2015 Nov 24. PubMed PMID: 26604244. 8: Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility. PLoS One. 2015 Nov 24;10(11):e0143243. doi: 10.1371/journal.pone.0143243. eCollection 2015. PubMed PMID: 26600013; PubMed Central PMCID: PMC4658040. 9: Lebedenko A, Semernik O. [OPTIMIZATION OF BRONCHODILATOR THERAPY FOR CHILDREN DURING ASTHMA EXACERBATION WITH ALLOWANCE FOR THE RISK OF DEVELOPMENT OF CARDIOHEMODYNAMIC DISORDERS]. Eksp Klin Farmakol. 2015;78(7):7-11. Russian. PubMed PMID: 26591200. 10: Tomczyk K, Rzymski P, Wilczak M. Have we achieved progress in tocolytic treatment?--results of a retrospective cohort study in a tertiary university hospital. Ginekol Pol. 2015 Jul;86(7):504-8. PubMed PMID: 26376527. 11: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PubMed PMID: 26304337. 12: Odnoshivkina UG, Sytchev VI, Nurullin LF, Giniatullin AR, Zefirov AL, Petrov AM. β2-adrenoceptor agonist-evoked reactive oxygen species generation in mouse atria: implication in delayed inotropic effect. Eur J Pharmacol. 2015 Oct 15;765:140-53. doi: 10.1016/j.ejphar.2015.08.020. Epub 2015 Aug 20. PubMed PMID: 26297975. 13: Soon E, Crosby A, Southwood M, Yang P, Tajsic T, Toshner M, Appleby S, Shanahan CM, Bloch KD, Pepke-Zaba J, Upton P, Morrell NW. Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension. Am J Respir Crit Care Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC. PubMed PMID: 26073741; PubMed Central PMCID: PMC4613895. 14: Okatan EN, Tuncay E, Hafez G, Turan B. Profiling of cardiac β-adrenoceptor subtypes in the cardiac left ventricle of rats with metabolic syndrome: Comparison with streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 2015 Jul;93(7):517-25. doi: 10.1139/cjpp-2014-0507. Epub 2015 Feb 13. PubMed PMID: 25994289. 15: Wang W, Zhang Y, Xu M, Zhang YY, He B. Fenoterol inhibits LPS-induced AMPK activation and inflammatory cytokine production through β-arrestin-2 in THP-1 cell line. Biochem Biophys Res Commun. 2015 Jun 26;462(2):119-23. doi: 10.1016/j.bbrc.2015.04.097. Epub 2015 Apr 28. PubMed PMID: 25930996. 16: Xiong L, Gao YQ, Li WH, Yang XL, Shimo SP. Simple and sensitive monitoring of β2-agonist residues in meat by liquid chromatography-tandem mass spectrometry using a QuEChERS with preconcentration as the sample treatment. Meat Sci. 2015 Jul;105:96-107. doi: 10.1016/j.meatsci.2015.03.013. Epub 2015 Mar 20. PubMed PMID: 25828164. 17: Plazinska A, Plazinski W, Jozwiak K. Agonist binding by the β2-adrenergic receptor: an effect of receptor conformation on ligand association-dissociation characteristics. Eur Biophys J. 2015 Apr;44(3):149-63. doi: 10.1007/s00249-015-1010-4. Epub 2015 Mar 1. PubMed PMID: 25726162; PubMed Central PMCID: PMC4359354. 18: Wnorowski A, Sadowska M, Paul RK, Singh NS, Boguszewska-Czubara A, Jimenez L, Abdelmohsen K, Toll L, Jozwiak K, Bernier M, Wainer IW. Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells. Cell Signal. 2015 May;27(5):997-1007. doi: 10.1016/j.cellsig.2015.02.012. Epub 2015 Feb 20. PubMed PMID: 25703025; PubMed Central PMCID: PMC4361792. 19: Potter PC, Ehrlich R, van Rooyen C, Fenemore B. Occupational sensitization to African penguin serum and mucus proteins. Ann Allergy Asthma Immunol. 2015 Apr;114(4):345-7. doi: 10.1016/j.anai.2014.12.023. Epub 2015 Jan 31. PubMed PMID: 25648565. 20: Poppinga WJ, Heijink IH, Holtzer LJ, Skroblin P, Klussmann E, Halayko AJ, Timens W, Maarsingh H, Schmidt M. A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L766-75. doi: 10.1152/ajplung.00301.2014. Epub 2015 Jan 30. PubMed PMID: 25637608; PubMed Central PMCID: PMC4499028.

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