MedKoo Cat#: 525042 | Name: Fenclonine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenclonine acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin. It has been used experimentally to treat carcinoid syndrome.

Chemical Structure

Fenclonine
Fenclonine
CAS#7424-00-2

Theoretical Analysis

MedKoo Cat#: 525042

Name: Fenclonine

CAS#: 7424-00-2

Chemical Formula: C9H10ClNO2

Exact Mass: 199.0400

Molecular Weight: 199.63

Elemental Analysis: C, 54.15; H, 5.05; Cl, 17.76; N, 7.02; O, 16.03

Price and Availability

Size Price Availability Quantity
1g USD 90.00 Ready to ship
5g USD 150.00 Ready to ship
10g USD 250.00 Ready to ship
25g USD 450.00 2 Weeks
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Related CAS #
Synonym
CP-10,188; CP10,188; CP 10,188; CP-10188; CP10188; CP 10188; Fenclonine; DL-3-(4-Chlorophenyl)alanine; Fenclonin; NSC 77370; p-Clorophenylalanine.
IUPAC/Chemical Name
Alanine, 3-(4-chlorophenyl)-, DL-
InChi Key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
SMILES Code
C(C(=O)O)(Cc1ccc(cc1)Cl)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Certificate of Analysis
Safety Data Sheet (SDS)
Biological target:
Fenclonine is an irreversible inhibitor of tryptophan (Trp) hydroxylase, the rate-limiting enzyme in serotonin biosynthesis.
In vitro activity:
N/A
In vivo activity:
N/A
Solvent mg/mL mM
Solubility
DMSO 1.5 7.51
Water 2.0 10.02
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 199.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Sicuteri F, Rumboldt Z, del Bene E. [Does fenclonine open up new perspectives in the treatment of impotence?]. Lijec Vjesn. 1975 May;97(5):307-10. Croatian. PubMed PMID: 128680. 2: Cremata VY Jr, Koe BK. Clinical and biochemical effects of fenclonine: a serotonin depletor. Dis Nerv Syst. 1968 May;29(5):Suppl:147-52. PubMed PMID: 5673619.