MedKoo Cat#: 525754 | Name: Niludipine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Niludipine is a Bis(2-propoxyethyl) analog of nifedipine and a calcium channel blocker. Niludipine is a safe antianginal Ca2+-antagonist with broad effectiveness for various types of angina pectoris. Niludipine is a highly effective drug for the treatment of both ischemic heart disease and essential hypertension.

Chemical Structure

Niludipine
CAS#22609-73-0

Theoretical Analysis

MedKoo Cat#: 525754

Name: Niludipine

CAS#: 22609-73-0

Chemical Formula: C25H34N2O8

Exact Mass: 490.2315

Molecular Weight: 490.55

Elemental Analysis: C, 61.21; H, 6.99; N, 5.71; O, 26.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Niludipina; Niludipinum; BAY-a 7168; Bay a 7168; Niludipine
IUPAC/Chemical Name
bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key
VZWXXKDFACOXNT-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3
SMILES Code
O=C(C1=C(C)NC(C)=C(C(OCCOCCC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 490.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ichihara K, Sakai K, Abiko Y. Effect of nifedipine and niludipine on myocardial pH in the ischemic canine heart. Arch Int Pharmacodyn Ther. 1986 Mar;280(1):58-73. PubMed PMID: 3718082. 2: Yasuda H, Tomita T, Fujita K, Shibata J, Tateda K, Yokota H, Igarashi T, Ogasawara S, Yamazaki M, Oyama Y. Clinical efficacy of niludipine in the treatment of angina pectoris. Arzneimittelforschung. 1984;34(5):614-9. PubMed PMID: 6540580. 3: Kusano E, Asano Y, Takeda K, Terao N, Hosoda S. Acute and chronic hypotensive effects of nifedipine and niludipine in hypertensive patients with chronic renal failure. Arzneimittelforschung. 1984;34(5):624-9. PubMed PMID: 6432001. 4: Ohneda A, Kobayashi T, Nihei J. Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas. Tohoku J Exp Med. 1983 Jun;140(2):153-9. PubMed PMID: 6351351. 5: Sashida H, Miyakawa K, Abiko Y. Effects of nifedipine and niludipine on ultrastructural changes induced by coronary occlusion in dog hearts. Exp Mol Pathol. 1982 Dec;37(3):413-26. PubMed PMID: 7151985. 6: Kuwajima I, Ueda K, Murakami M. A study on the effects of niludipine in hypertensive patients. Arzneimittelforschung. 1982;32(4):398-402. PubMed PMID: 7201809. 7: Kurita A, Isojima K, Mizuno K, Aozaki N, Kondo S, Hosono K. Effects of new calcium channel blocker of niludipine on the coronary hemodynamics, diastolic properties, and metabolic responses to tachycardia stress in patients with coronary disease. Cathet Cardiovasc Diagn. 1982;8(4):373-81. PubMed PMID: 7127462. 8: Ogawa K, Ito T, Ban M, Hashimoto H, Nizoe K, Mochizuki M, Sakai K, Watanabe J, Kanayama H, Okumura K, Sone T, Imura K, Uno T, Shikano M, Kotaka K, Miyazaki Y. Clinical effectiveness of niludipine in patients with ischemic heart disease. Arzneimittelforschung. 1982;32(5):542-7. PubMed PMID: 6809015. 9: Aoki K, Sato K. Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic). Arzneimittelforschung. 1982;32(9):1141-5. PubMed PMID: 6756418. 10: Fagbemi O, Parratt JR. Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia. Br J Pharmacol. 1981 Sep;74(1):12-4. PubMed PMID: 7272595; PubMed Central PMCID: PMC2071867. 11: Ogawa K, Wakamasu Y, Ito T, Suzuki T, Yamazaki N. Comparative coronary vasodilatory effects of nifedipine and niludipine. Arzneimittelforschung. 1981;31(5):770-3. PubMed PMID: 7196733. 12: Maeda K, Tanaka C, Yagi Y, Fujita K, Oshiro T, Itsumi H, Furukawa K, Imako K, Kurata N, Tsukano Y, Shiota K. Treatment of angina pectoris patients with niludipine a new calcium antagonistic drug. Arzneimittelforschung. 1981;31(5):830-4. PubMed PMID: 6791665. 13: Nomura H, Nagata K, Futamura Y, Mochizuki K, Hama Y, Sotobata I, Yasui S. Effects of niludipine on regional myocardial blood flow and regional myocardial function in the dog with partial occlusion of the coronary artery. Arzneimittelforschung. 1980;30(8):1258-62. PubMed PMID: 7192140. 14: Ichihara K, Ichihara M, Abiko Y. Effect of niludipine on ischemic myocardial metabolism in the dog. Arzneimittelforschung. 1980;30(5):785-91. PubMed PMID: 7190421. 15: Kodama I, Hirata Y, Toyama J, Yamada K. Effects of niludipine (Bay-a-7168) on transmembrane action potentials of rabbit sinus node cells and atrial muscle fibers. J Cardiovasc Pharmacol. 1980;2(2):145-53. PubMed PMID: 6171682. 16: Hiwatari M, Taira N. Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs. Arzneimittelforschung. 1979;29(9):1373-6. PubMed PMID: 583244. 17: Hashimoto K, Takeda K, Katano Y, Nakagawa Y, Tsukada T, Hashimoto T, Shimamoto N, Sakai K, Otorii T, Imai S. Effects of niludipine (Bay a 7168) on the cardiovascular system with a note on its calcium-antagonistic effects. Arzneimittelforschung. 1979;29(9):1368-73. PubMed PMID: 583243. 18: Taira N, Narimatsu A, Satoh K, Himori N, Imai Y, Hiwatari M. Cardiovascular actions of niludipine (BAY a 7168), a new dihydropyridine vasodilator, in the dog. Arzneimittelforschung. 1979;29(2):246-55. PubMed PMID: 582137. 19: Fleckenstein A, Fleckenstein-Grün G, Byon YK, Haastert HP, Späh F. [Comparative studies on the basic Ca2+ antagonistic activities of niludipine (Bay a 7168) and nifedipine (Bay a 1040) on the myocardium, myometrium and vessels of smooth muscles (author's transl)]. Arzneimittelforschung. 1979;29(2):230-46. German. PubMed PMID: 582136.