Synonym
693B; Astaril; Bayer 693; Ethylstibamine; p-Aminobenzenestibonic acid; Stibanilic acid; Neostibosan
IUPAC/Chemical Name
(4-aminophenyl)stibonic acid
InChi Key
NLPWTTIYIIOESZ-UHFFFAOYSA-L
InChi Code
InChI=1S/C6H6N.2H2O.O.Sb/c7-6-4-2-1-3-5-6;;;;/h2-5H,7H2;2*1H2;;/q;;;;+2/p-2
SMILES Code
O=[Sb](C1=CC=C(N)C=C1)(O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
263.89
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hadjikakou SK, Ozturk II, Banti CN, Kourkoumelis N, Hadjiliadis N. Recent advances on antimony(III/V) compounds with potential activity against tumor cells. J Inorg Biochem. 2015 Dec;153:293-305. doi: 10.1016/j.jinorgbio.2015.06.006. Epub 2015 Jun 10. Review. PubMed PMID: 26092367.
2: Cambronero Galache M, Martínez Cortés F, Bódalo Herrero A, Courel Grijalba A, Casado Flores J, Casquero Junquera J. [Kala-azar in childhood. 20 year review]. An Esp Pediatr. 1983 Jan;18(1):28-32. Spanish. PubMed PMID: 6870075.
3: Duke BO. The effects of drugs on Onchocerca volvulus. 2. The antimonial preparations TWSb and MSbE. Bull World Health Organ. 1968;39(2):147-55. PubMed PMID: 4881067; PubMed Central PMCID: PMC2554559.
4: IVADY G, FRIEDRICH E. [Comparative studies on the efficacy of pentamidine, Solustibosan and Neostibosan against Candida albicans]. Dtsch Gesundheitsw. 1960 Oct 27;15:2130-2. German. PubMed PMID: 13718206.
5: FIGI FA. [Not Available]. Am Clin. 1948 Aug;13(2):152-8. Undetermined Language. PubMed PMID: 18881249.
6: MARTINEZ-VILLAFANE H, LANG AA. The treatment of schistosomiasis mansoni with neostibosan. Bol Asoc Med P R. 1948 Jun;40(6):128-30. PubMed PMID: 18881259.
7: CULBERTSON JT. Treatment of filariasis with neostibosan and some other compounds. Ann N Y Acad Sci. 1948 May 25;50(21-26):73-88. PubMed PMID: 18860240.
8: SMITH RG, CHEN JY, MAGEE M. The distribution and excretion of antimony following administration of antimony potassium tartrate and neostibosan. Fed Proc. 1948 Mar;7(1 Pt 1):256. PubMed PMID: 18934441.
9: TRENT SC. Anthiomaline and neostibosan in the treatment of filariasis, (Dirofilaria immitis.). PR J Public Health Trop Med. 1948 Mar;23(3):311-60. PubMed PMID: 18880270.
10: HERNANDEZ-MORALES F, OLIVER-GONZALEZ J, PRATT CK. Treatment of Schistosomiasis mansoni with neostibosan. Proc Soc Exp Biol Med. 1946 Oct;63(1):218. PubMed PMID: 20274324.
11: IKEJIANI O, MAUTNER LS. Changes in the leucocyte picture in experimental trypanosomiasis by administration of neostibosan and neostam. J Pharmacol Exp Ther. 1946 Aug;87(4 Suppl):343-9. PubMed PMID: 20279253.
12: CULBERTSON JT, ROSE HM, OLIVER-GONZALEZ J. Chemotherapy of filariasis due to Wuchereria bancrofti with neostibosan. Am J Hyg. 1946 Mar;43:145-51. PubMed PMID: 21018328.
13: CULBERTSON JT, ROSE HM, OLIVER GONZALEZ J. The chemotherapy of human filariasis by the administration of neostibosan. Am J Trop Med Hyg. 1945;25:403-6. PubMed PMID: 21005336.
