MedKoo Cat#: 562893 | Name: CBFβ Inhibitor
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CBFβ Inhibitor is a cell-permeable inhibitor of CBFbeta,. It acts by binding to core binding factor beta.

Chemical Structure

CBFβ Inhibitor
CBFβ Inhibitor
CAS#493028-20-9

Theoretical Analysis

MedKoo Cat#: 562893

Name: CBFβ Inhibitor

CAS#: 493028-20-9

Chemical Formula: C12H14N2OS

Exact Mass: 234.0827

Molecular Weight: 234.31

Elemental Analysis: C, 61.51; H, 6.02; N, 11.96; O, 6.83; S, 13.68

Price and Availability

Size Price Availability Quantity
5mg USD 285.00 2 Weeks
10mg USD 485.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
CBFβ Inhibitor; CBFbeta Inhibitor;
IUPAC/Chemical Name
5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
InChi Key
QHRCVGXBBIRPTE-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
SMILES Code
NC1=NC(C2=CC=C(OC)C=C2)=C(CC)S1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 234.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Castilla LH, Bushweller JH. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia. Adv Exp Med Biol. 2017;962:229-244. doi: 10.1007/978-981-10-3233-2_15. Review. PubMed PMID: 28299661. 2: Berg T. Small-molecule inhibitors of protein-protein interactions. Curr Opin Drug Discov Devel. 2008 Sep;11(5):666-74. Review. PubMed PMID: 18729018. 3: Imai O, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa S, Chiba S, Mitani K, Hirai H. Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome. Leuk Lymphoma. 2002 Mar;43(3):617-21. Review. PubMed PMID: 12002768. 4: Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M, Marín-Padilla M. Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 1999 Apr 1;59(7 Suppl):1789s-1793s. Review. PubMed PMID: 10197598.