Synonym
Paratect; Thelmesan; Banminth-II; BanminthII; Banminth II; Rumatel-88 Rumatel88; Rumatel 88; Morantel tartrate
IUPAC/Chemical Name
(E)-1-methyl-2-(2-(3-methylthiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine 2,3-dihydroxysuccinate
InChi Key
GGXQONWGCAQGNA-FXRZFVDSSA-N
InChi Code
InChI=1S/C12H16N2S.C4H6O6/c1-10-6-9-15-11(10)4-5-12-13-7-3-8-14(12)2;5-1(3(7)8)2(6)4(9)10/h4-6,9H,3,7-8H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/b5-4+;
SMILES Code
CC1=C(/C=C/C2=NCCCN2C)SC=C1.OC(C(C(O)=O)O)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Morantel tartrate is a broad spectrum anthelmintic, effective and low toxicity.
In vitro activity:
Macroscopic currents evoked by acetylcholine (ACh) from nAChRs expressed in Xenopus laevis oocytes increase up to 8-fold in the presence of low concentrations of morantel (< or =10 microM); the magnitude of the potentiation depends on both agonist and modulator concentrations. Instead, using outside-out patch-clamp recordings, this study demonstrate that morantel increases the frequency of single-channel openings and alters the bursting characteristics of the openings in a manner consistent with enhanced channel gating; these results quantitatively explain the macroscopic current potentiation.
Reference: Mol Pharmacol. 2008 Aug;74(2):466-75. https://pubmed.ncbi.nlm.nih.gov/18458055/
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
33.0 |
89.09 |
| DMSO |
73.0 |
197.07 |
| Ethanol |
1.0 |
2.70 |
| PBS (pH 7.2) |
10.0 |
27.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
370.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
Wu TY, Smith CM, Sine SM, Levandoski MM. Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors. Mol Pharmacol. 2008 Aug;74(2):466-75. doi: 10.1124/mol.107.044388. Epub 2008 May 5. PMID: 18458055; PMCID: PMC2587017.
In vitro protocol:
Wu TY, Smith CM, Sine SM, Levandoski MM. Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors. Mol Pharmacol. 2008 Aug;74(2):466-75. doi: 10.1124/mol.107.044388. Epub 2008 May 5. PMID: 18458055; PMCID: PMC2587017.
1: Reinemeyer CR, Pringle JK. Evaluation of the efficacy and safety of morantel tartrate in domestic goats. Vet Hum Toxicol. 1993;35 Suppl 2:57-61. PubMed PMID: 8236769.
2: Lanusse CE, Gascon LH, Ranjan S, Prichard RK. Morantel tartrate release from a long-acting intraruminal device in cattle: pharmacokinetics and gastrointestinal distribution. J Vet Pharmacol Ther. 1992 Jun;15(2):117-23. PubMed PMID: 1433473.
3: Borgsteede FH. Further studies with a strain of Ostertagia ostertagi resistant to morantel tartrate. Int J Parasitol. 1991 Nov;21(7):867-70. PubMed PMID: 1774123.
4: Borgsteede FH. The difference between two strains of Ostertagia ostertagi in resistance to morantel tartrate. Int J Parasitol. 1988 Jun;18(4):499-502. PubMed PMID: 3417377.
5: Lynch MJ, Mosher FR, Dimmock ME, Brunner LA, Babcock WE, McManus RF, Wheelhouse RK. Determination of depletion and statistical distribution of morantel-related residues in bovine milk following administration of morantel tartrate to dairy cows. J Assoc Off Anal Chem. 1986 Nov-Dec;69(6):935-8. PubMed PMID: 3804945.
6: Block E, Takagi H, Downey BR, Rau ME, Gadbois P. Efficacy of morantel tartrate in a sustained release bolus on the control of subclinical gastrointestinal parasitism in first-year grazing dairy replacements. J Dairy Sci. 1985 Sep;68(9):2361-71. PubMed PMID: 4067049.
7: Goras JT, Gauthier AR. Liquid chromatographic determination of morantel tartrate in cattle feed. J Assoc Off Anal Chem. 1985 May-Jun;68(3):598-601. PubMed PMID: 4019388.
8: Ciordia H, Calvert GV, McCampbell HC. Effect of an anthelmintic program with morantel tartrate on the performance of beef cattle. J Anim Sci. 1982 Jun;54(6):1111-4. PubMed PMID: 7107530.
9: Kelly JD, Whitlock HV, Porter CJ, Griffin D, Martin IC. Anthelmintic efficacy of low-dose phenothiazine against strains of sheep nematodes susceptible or resistant to thiabendazole, levamisole and morantel tartrate: efficiency against sequentially administered infections. Res Vet Sci. 1981 Mar;30(2):170-4. PubMed PMID: 7255907.
10: Whitlock HV, Sangster NC, Gunawan M, Porter CJ, Kelly JD. Trichostrongylus colubriformis and Ostertagia sp resistant to levamisole, morantel tartrate and thiabendazole: isolation into pure strain and anthelmintic titration. Res Vet Sci. 1980 Jul;29(1):31-5. PubMed PMID: 7455351.
11: Le Jambre LF, Southcott WH, Dash KM. Development of simulatenous resistance in Ostertagia circumcincta to thiabendazole, morantel tartrate and levamisole. Int J Parasitol. 1978 Dec;8(6):443-7. PubMed PMID: 748216.
12: Le Jambre LF, Southcott WH, Dash KM. Resistance of selected lines of Ostertagia circumcincta to thiabendazole, morantel tartrate and levamisole. Int J Parasitol. 1977 Dec;7(6):473-9. PubMed PMID: 598966.
13: Troncy PM, Oumate O. [Experimentation in Chad with morantel tartrate for the control of gastrointestinal nematodes in the dromedary (Camelus dromedarius)]. Rev Elev Med Vet Pays Trop. 1976;29(3):229-32. French. PubMed PMID: 1005846.
14: Vassiliades G, Toure SM. [Experimental treatment of strongylosis of the digestive tract of sheep in tropical zones with morantel tartrate]. Rev Elev Med Vet Pays Trop. 1975;28(4):481-9. French. PubMed PMID: 1230887.
15: Gibson TE, Parfitt JW. The action of morantel tartrate against nematodes in sheep. Vet Rec. 1973 Oct 13;93(15):423-5. PubMed PMID: 4772566.
16: Cornwell RL, Jones RM, Pott JM. Critical trials of morantel tartrate in equine strongylosis. Vet Rec. 1973 Jul 28;93(4):94-8. PubMed PMID: 4760934.
17: Conway DP, DeGoosh C, Arakawa A. Anthelmintic efficacy of morantel tartrate in cattle. Am J Vet Res. 1973 May;34(5):621-2. PubMed PMID: 4703507.
18: Troncy PM, Oumate O. [Use of Morantel tartrate for zebu cattle in Chad. I. Action on Strongyloidea]. Rev Elev Med Vet Pays Trop. 1973;26(2):189-98. French. PubMed PMID: 4805571.
19: Cornwell RL, Jones RM, Pott JM. Critical trials with morantel tartrate against Parascaris eguorum. Res Vet Sci. 1973 Jan;14(1):134-6. PubMed PMID: 4707893.
20: Hiepe T. [Effectiveness of morantel tartrate against nematode infections in race horses]. Schweiz Arch Tierheilkd. 1972 Dec;114(12):613-4. German. PubMed PMID: 4675474.
