CX546 | CAS#215923-54-9 | AMPA Receptor

MedKoo Cat#: 524918 | Name: CX546

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CX546 is an AMPA receptor potentiator. It binds specifically to the agonist bound non-desensitized receptor, and most likely destabilizing the desensitized receptor conformation. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.

Chemical Structure

CX546

CAS#215923-54-9

Theoretical Analysis

MedKoo Cat#: 524918

Name: CX546

CAS#: 215923-54-9

Chemical Formula: C14H17NO3

Exact Mass: 247.1208

Molecular Weight: 247.29

Elemental Analysis: C, 68.00; H, 6.93; N, 5.66; O, 19.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; BDP-17.

IUPAC/Chemical Name

2,3-Dihydro-1,4-benzodioxin-7-yl-(1-piperidyl)methanone

InChi Key

LJUNPHMOGNFFOS-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

SMILES Code

c1cc2c(cc1C(=O)N3CCCCC3)OCCO2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 247.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cavalla D, Chianelli F, Korsak A, Hosford PS, Gourine AV, Marina N. Tianeptine prevents respiratory depression without affecting analgesic effect of opiates in conscious rats. Eur J Pharmacol. 2015 Aug 15;761:268-72. doi: 10.1016/j.ejphar.2015.05.067. Epub 2015 Jun 8. PubMed PMID: 26068549. 2: Chang PK, Prenosil GA, Verbich D, Gill R, McKinney RA. Prolonged ampakine exposure prunes dendritic spines and increases presynaptic release probability for enhanced long-term potentiation in the hippocampus. Eur J Neurosci. 2014 Sep;40(5):2766-76. doi: 10.1111/ejn.12638. Epub 2014 Jun 13. PubMed PMID: 24925283. 3: Modvig A, Andersen TL, Taaning RH, Lindhardt AT, Skrydstrup T. Two-chamber hydrogen generation and application: access to pressurized deuterium gas. J Org Chem. 2014 Jun 20;79(12):5861-8. doi: 10.1021/jo500801t. Epub 2014 Jun 11. PubMed PMID: 24870212. 4: O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. Review. PubMed PMID: 17504104. 5: O'Neill MJ, Bleakman D, Zimmerman DM, Nisenbaum ES. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. Review. PubMed PMID: 15180479.