NSC-405020 | CAS#7497-07-6 | MT1-MMP inhibitor

MedKoo Cat#: 530357 | Name: NSC-405020

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-405020 is a Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Inhibition of MT1-MMP expression by NSC405020 resulted in decrease of arsenic-mediated invasion of HSC5 cells involving decrease in phosphorylated extracellular signal-regulated kinases (pERK).

Chemical Structure

NSC-405020

CAS#7497-07-6

Theoretical Analysis

MedKoo Cat#: 530357

Name: NSC-405020

CAS#: 7497-07-6

Chemical Formula: C12H15Cl2NO

Exact Mass: 259.0531

Molecular Weight: 260.16

Elemental Analysis: C, 55.40; H, 5.81; Cl, 27.25; N, 5.38; O, 6.15

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 1,950.00	2 Weeks
1g	USD 2,650.00	2 Weeks
2g	USD 3,950.00	2 Weeks
5g	USD 5,650.00	2 Weeks

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Related CAS #

No Data

Synonym

NSC-405020; NSC 405020; NSC405020.

IUPAC/Chemical Name

3,4-Dichloro-N-(1-methylbutyl)benzamide

InChi Key

ARDYECYBETXQFD-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)

SMILES Code

O=C(NC(C)CCC)C1=CC=C(Cl)C(Cl)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NSC 405020 is a specific MMP14 inhibitor.

In vitro activity:

TBD

In vivo activity:

Sh3bp2KI/KI mice also deficient in the FBJ osteosarcoma oncogene (c-Fos) still exhibit noticeable bone erosion at the distal tibia even in the absence of osteoclasts at 12 weeks old. Importantly, administration of NSC405020, an MMP14 inhibitor targeted to the hemopexin (PEX) domain, suppressed bone erosion in c-Fos-deficient Sh3bp2KI/KI mice. Reference: J Bone Miner Res. 2018 Jan;33(1):167-181. https://pubmed.ncbi.nlm.nih.gov/28914985/

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	115.31
	DMSO	89.5	344.04
	Ethanol	36.0	138.40
	Ethanol:PBS (pH 7.2) (1:3)	0.3	0.96

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Kittaka M, Mayahara K, Mukai T, Yoshimoto T, Yoshitaka T, Gorski JP, Ueki Y. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts. J Bone Miner Res. 2018 Jan;33(1):167-181. doi: 10.1002/jbmr.3295. Epub 2017 Nov 2. PMID: 28914985; PMCID: PMC5771992.

In vitro protocol:

TBD

In vivo protocol:

1: Thang ND, Yajima I, Kumasaka MY, Kato M. Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma. PLoS One. 2014 May 9;9(5):e96945. doi: 10.1371/journal.pone.0096945. PubMed PMID: 24816914; PubMed Central PMCID: PMC4016145.