MedKoo Cat#: 526707 | Name: BCX-1470

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BCX 1470 is a potent and selective Serine protease inhibitor. CX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. BCX 1470 may be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental.

Chemical Structure

BCX-1470
BCX-1470
CAS#217099-43-9 (free

Theoretical Analysis

MedKoo Cat#: 526707

Name: BCX-1470

CAS#: 217099-43-9 (free

Chemical Formula: C14H10N2O2S2

Exact Mass: 302.0184

Molecular Weight: 302.37

Elemental Analysis: C, 55.61; H, 3.33; N, 9.26; O, 10.58; S, 21.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
BCX 1470; BCX-1470; BCX 1470; BCX-1470 HCl.
IUPAC/Chemical Name
(2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate
InChi Key
OTGQTQBPQCRNRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10N2O2S2/c15-13(16)12-6-8-3-4-9(7-11(8)20-12)18-14(17)10-2-1-5-19-10/h1-7H,(H3,15,16)
SMILES Code
O=C(C1=CC=CS1)OC2=CC=C3C=C(C(N)=N)SC3=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related: 217099-43-9 (BCX-1470 free) 217099-44-0 (BCX-1470 mesylate).

Preparing Stock Solutions

The following data is based on the product molecular weight 302.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE. The Arthus reaction in rodents: species-specific requirement of complement. J Immunol. 2000 Jan 1;164(1):463-8. PubMed PMID: 10605043.