VL-0395 | CAS#620167-11-5 | CCK1 Receptor Antagonist

MedKoo Cat#: 532878 | Name: VL-0395

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VL-0395 is a CCK1 receptor antagonist.

Chemical Structure

VL-0395

CAS#620167-11-5

Theoretical Analysis

MedKoo Cat#: 532878

Name: VL-0395

CAS#: 620167-11-5

Chemical Formula: C26H23N5O4

Exact Mass: 469.1750

Molecular Weight: 469.50

Elemental Analysis: C, 66.51; H, 4.94; N, 14.92; O, 13.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

VL-0395, VL 0395, VL0395

IUPAC/Chemical Name

3-[[3-[(5-carbamimidoyl1H-indole-2-carbonyl)amino]benzoyl]amino]-3-phenylpropanoic acid

InChi Key

RVWSCZNGPOUASU-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H23N5O4/c27-24(28)16-9-10-20-18(11-16)13-22(30-20)26(35)29-19-8-4-7-17(12-19)25(34)31-21(14-23(32)33)15-5-2-1-3-6-15/h1-13,21,30H,14H2,(H3,27,28)(H,29,35)(H,31,34)(H,32,33)

SMILES Code

O=C(O)CC(NC(C1=CC=CC(NC(C(N2)=CC3=C2C=CC(C(N)=N)=C3)=O)=C1)=O)C4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 469.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pavan MV, Lassiani L, Berti F, Stefancich G, Ciogli A, Gasparrini F, Mennuni L, Ferrari F, Escrieut C, Marco E, Makovec F, Fourmy D, Varnavas A. New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R). J Med Chem. 2011 Aug 25;54(16):5769-85. doi: 10.1021/jm200438b. Epub 2011 Jul 20. PubMed PMID: 21728335. 2: Lassiani L, Pavan MV, Berti F, Kokotos G, Markidis T, Mennuni L, Makovec F, Varnavas A. Anthranilic acid based CCK1 receptor antagonists: blocking the receptor with the same 'words' of the endogenous ligand. Bioorg Med Chem. 2009 Mar 15;17(6):2336-50. doi: 10.1016/j.bmc.2009.02.012. Epub 2009 Feb 14. PubMed PMID: 19261479. 3: Varnavas A, Lassiani L, Valenta V, Ciogli A, Gasparrini F, Mennuni L, Makovec F. N-terminal anthranoyl-phenylalanine derivatives as CCK1 receptor antagonists: the final approach. Med Chem. 2005 Sep;1(5):501-17. PubMed PMID: 16787335. 4: De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A. Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes". J Med Chem. 2006 Apr 20;49(8):2456-62. PubMed PMID: 16610788. 5: Varnavas A, Lassiani L, Valenta V, Mennuni L, Makovec F, Hadjipavlou-Litina D. Anthranilic acid based CCK1 receptor antagonists: preliminary investigation on their second "touch point". Eur J Med Chem. 2005 Jun;40(6):563-81. PubMed PMID: 15922840. 6: Varnavas A, Lassiani L, Valenta V, Berti F, Tontini A, Mennuni L, Makovec F. Anthranilic acid based CCK1 antagonists: the 2-indole moiety may represent a "needle" according to the recent homonymous concept. Eur J Med Chem. 2004 Jan;39(1):85-97. PubMed PMID: 14987837. 7: Varnavas A, Lassiani L, Valenta V, Berti F, Mennuni L, Makovec F. Anthranilic acid derivatives: a new class of non-peptide CCK1 receptor antagonists. Bioorg Med Chem. 2003 Mar 6;11(5):741-51. PubMed PMID: 12538004.