ONO-2920632 | TREK-1 and TREK-2 activator | CAS#2230296-66-7

MedKoo Cat#: 128845 | Name: ONO-2920632

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ONO-2920632 is a TREK-1 and TREK-2 activator.

Chemical Structure

ONO-2920632

CAS#2230296-66-7

Theoretical Analysis

MedKoo Cat#: 128845

Name: ONO-2920632

CAS#: 2230296-66-7

Chemical Formula: C15H10F4N4O2

Exact Mass: 354.0740

Molecular Weight: 354.26

Elemental Analysis: C, 50.86; H, 2.85; F, 21.45; N, 15.82; O, 9.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ONO-2920632; ONO 2920632; ONO2920632; VU6011887

IUPAC/Chemical Name

N-(2-fluoro-4-(trifluoromethoxy)benzyl)-[1,2,4]triazolo[1,5-a]pyridine-6-carboxamide

InChi Key

KDTQFQYXTWVBCC-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H10F4N4O2/c16-12-5-11(25-15(17,18)19)3-1-9(12)6-20-14(24)10-2-4-13-21-8-22-23(13)7-10/h1-5,7-8H,6H2,(H,20,24)

SMILES Code

FC(C=C(OC(F)(F)F)C=C1)=C1CNC(C2=CN3N=CN=C3C=C2)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 354.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Yashiro K, Iwaki Y, Urata H, Kokubo M, Mori T, Sekioka Y, Isami K, Kato J, Wieting J, McGowan KM, Bridges TM, Boutaud O, Engers DW, Denton JS, Kurata H, Lindsley CW. Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound. ACS Chem Neurosci. 2025 Mar 5;16(5):960-967. doi: 10.1021/acschemneuro.5c00032. Epub 2025 Feb 21. PMID: 39981749; PMCID: PMC11887051.