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MedKoo Cat#: 524887 | Name: CS 476

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CS 476 is an oral hypoglycaemic agent.

Chemical Structure

CS 476
CS 476
CAS#41177-35-9

Theoretical Analysis

MedKoo Cat#: 524887

Name: CS 476

CAS#: 41177-35-9

Chemical Formula: C24H29N3O5S

Exact Mass: 471.1828

Molecular Weight: 471.57

Elemental Analysis: C, 61.13; H, 6.20; N, 8.91; O, 16.96; S, 6.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
CS 476; CS-476; CS476; NOVO CS 476; NSC 302998.
IUPAC/Chemical Name
N-(4-(2-(2,3-Dihydrobenzo(b)furan-7-carboxamido)ethyl)benzenesulfonyl)-N'-cyclohexylurea
InChi Key
RNQMWIVFHOCVMM-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29N3O5S/c28-23(21-8-4-5-18-14-16-32-22(18)21)25-15-13-17-9-11-20(12-10-17)33(30,31)27-24(29)26-19-6-2-1-3-7-19/h4-5,8-12,19H,1-3,6-7,13-16H2,(H,25,28)(H2,26,27,29)
SMILES Code
S(NC(NC1CCCCC1)=O)(c1ccc(CCNC(c2c3OCCc3ccc2)=O)cc1)(=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 471.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ma M, Dai Y, Zou JL, Wang L, Pan K, Fu HG. Synthesis of iron oxide/partly graphitized carbon composites as a high-efficiency and low-cost cathode catalyst for microbial fuel cells. ACS Appl Mater Interfaces. 2014 Aug 27;6(16):13438-47. doi: 10.1021/am501844p. Epub 2014 Aug 14. PubMed PMID: 25084054. 2: Taylor T, Gotfredsen C, Chasseaud LF, Elsom LF, Franklin ER. Disposition of the hypoglycaemic sulphonylurea CS 476. Acta Pharmacol Toxicol (Copenh). 1977 Jul;41(1):25-32. PubMed PMID: 578376. 3: Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-7-carboxamid o)-ethyl)-benzenesulphonyl]-N'-cyclohexlurea (NOVO CS 476). III. General pharmacological studies. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):234-40. PubMed PMID: 402792. 4: Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-m-carboxamido)-ethyl)-benzenesulphonyl]-N'-cycl ohexylurea (NOVO CS 476). I. Pharmacological studies on the hypoglycaemic effect. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):216-26. PubMed PMID: 402791. 5: Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo (b) furan-7-carboxamido)-ethyl)-benzenesulphonyl]-N'-cyclohexylurea (NOVO CS 476). II. Pharmacological studies on the mechanism of action. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):227-33. PubMed PMID: 190857.

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