MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 414515 | Name: NPS-2143

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPS-2143 is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor, and consequently stimulates release of parathyroid hormone.

Chemical Structure

NPS-2143
NPS-2143
CAS#284035-33-2

Theoretical Analysis

MedKoo Cat#: 414515

Name: NPS-2143

CAS#: 284035-33-2

Chemical Formula: C24H25ClN2O2

Exact Mass: 408.1605

Molecular Weight: 408.93

Elemental Analysis: C, 70.49; H, 6.16; Cl, 8.67; N, 6.85; O, 7.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
NPS-2143; NPS2143; NPS 2143; SB-262470; SB262470; SB 262470
IUPAC/Chemical Name
Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)-
InChi Key
PZUJQWHTIRWCID-HXUWFJFHSA-N
InChi Code
InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
SMILES Code
N#CC1=C(OC[C@H](O)CNC(C)(C)CC2=CC=C3C=CC=CC3=C2)C=CC=C1Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 408.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang ZL, Li ZR, Li JS, Wang SR. Calcium-sensing receptor antagonist NPS-2143 suppresses proliferation and invasion of gastric cancer cells. Cancer Gene Ther. 2020 Aug;27(7-8):548-557. doi: 10.1038/s41417-019-0128-4. Epub 2019 Aug 8. PMID: 31391530. 2: Lee JW, Park HA, Kwon OK, Park JW, Lee G, Lee HJ, Lee SJ, Oh SR, Ahn KS. NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation. Mol Immunol. 2017 Oct;90:150-157. doi: 10.1016/j.molimm.2017.07.012. Epub 2017 Aug 8. PMID: 28800474. 3: Wang S, Qiu L, Song H, Dang N. NPS - 2143 (hydrochloride) inhibits melanoma cancer cell proliferation and induces autophagy and apoptosis. Med Sci (Paris). 2018 Oct;34 Focus issue F1:87-93. doi: 10.1051/medsci/201834f115. Epub 2018 Nov 7. PMID: 30403181. 4: Lo Giudice M, Mihalik B, Turi Z, Dinnyés A, Kobolák J. Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC- Derived Neurons. J Alzheimers Dis. 2019;72(3):885-899. doi: 10.3233/JAD-190602. PMID: 31640098; PMCID: PMC6918902. 5: Chiarini A, Armato U, Hu P, Dal Prà I. CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes. Cells. 2020 Jun 2;9(6):1386. doi: 10.3390/cells9061386. PMID: 32498476; PMCID: PMC7349863. 6: Chen CY, Hour MJ, Lin WC, Wong KL, Shiao LR, Cheng KS, Chan P, Leung YM. Antagonism of Ca2+-sensing receptors by NPS 2143 is transiently masked by p38 activation in mouse brain bEND.3 endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul;392(7):823-832. doi: 10.1007/s00210-019-01637-y. Epub 2019 Mar 2. PMID: 30826858. 7: Rybczynska A, Lehmann A, Jurska-Jasko A, Boblewski K, Orlewska C, Foks H, Drewnowska K. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191(1):189-95. doi: 10.1677/joe.1.06924. PMID: 17065402. 8: Hannan FM, Walls GV, Babinsky VN, Nesbit MA, Kallay E, Hough TA, Fraser WD, Cox RD, Hu J, Spiegel AM, Thakker RV. The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1). Endocrinology. 2015 Sep;156(9):3114-21. doi: 10.1210/en.2015-1269. Epub 2015 Jun 8. PMID: 26052899; PMCID: PMC4541614. 9: Chiarini A, Armato U, Liu D, Dal Prà I. Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes. Sci Rep. 2017 Apr 28;7(1):1277. doi: 10.1038/s41598-017-01215-3. PMID: 28455519; PMCID: PMC5430644. 10: Chen Y, Ju Y, Li C, Yang T, Deng Y, Luo Y. Design, synthesis, and antibacterial evaluation of novel derivatives of NPS-2143 for the treatment of methicillin-resistant S. aureus (MRSA) infection. J Antibiot (Tokyo). 2019 Jul;72(7):545-554. doi: 10.1038/s41429-019-0177-9. Epub 2019 Apr 2. PMID: 30940910.