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MedKoo Cat#: 525653 | Name: MK761

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK761 is a new class of compound which has beta adrenoceptor antagonist and vasodilating properties in a single molecule. The compound has in vitro beta adrenoceptor blocking activity in the isolated cat heart papillary muscle and isolated rat atria. It is approximately as potent as timolol and pindolol in blocking cardiac and vascular beta adrenergic receptors.

Chemical Structure

MK761
MK761
CAS#65321-41-7

Theoretical Analysis

MedKoo Cat#: 525653

Name: MK761

CAS#: 65321-41-7

Chemical Formula: C13H19N3O2

Exact Mass: 249.1477

Molecular Weight: 249.31

Elemental Analysis: C, 62.63; H, 7.68; N, 16.85; O, 12.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-761; MK 761; MK761
IUPAC/Chemical Name
(S)-2-(3-(tert-butylamino)-2-hydroxypropoxy)nicotinonitrile
InChi Key
KVTGTAZVDSYIPY-NSHDSACASA-N
InChi Code
InChI=1S/C13H19N3O2/c1-13(2,3)16-8-11(17)9-18-12-10(7-14)5-4-6-15-12/h4-6,11,16-17H,8-9H2,1-3H3/t11-/m0/s1
SMILES Code
N#CC1=CC=CN=C1OC[C@@H](O)CNC(C)(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 249.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sweet CS, Hall RA, Columbo JM, Wenger HC, Backlund E, Morgan G, Gaul SL, Scriabine A. Beta adrenoceptor blocking properties of MK-761. J Pharmacol Exp Ther. 1979 Oct;211(1):195-9. PubMed PMID: 40012. 2: Sweet CS, Scriabine A, Weitz D, Ludden CT, Minsker DH, Stone CA. Antihypertensive and hemodynamic properties of 2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine HCl (MK-761). J Pharmacol Exp Ther. 1979 Oct;211(1):200-6. PubMed PMID: 114619. 3: Mostaghim R, Maddox YT, Ramwell PW. Endothelial potentiation of relaxation response to beta adrenoceptor blocking agents. J Pharmacol Exp Ther. 1986 Dec;239(3):797-801. PubMed PMID: 2879033. 4: Scriabine A, Ludden CT, Morgan G, Baldwin JJ. Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. Experientia. 1979 Dec 15;35(12):1634-7. PubMed PMID: 42553. 5: Sybertz EJ, Baum T, Pula KK, Nelson S, Eynon E, Sabin C. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58. PubMed PMID: 6182405. 6: Lefer AM, Lefer DJ, Levin RJ. Actions of non-cardiodepressant beta-adrenergic blocking agents in hemorrhagic shock. Adv Shock Res. 1980;3:167-74. PubMed PMID: 6118024. 7: Baum T, Sybertz EJ. Antihypertensive actions of an isomer of labetalol and other vasodilator-beta-adrenoceptor blockers. Fed Proc. 1983 Feb;42(2):176-81. PubMed PMID: 6130003. 8: Vickers S, Duncan CA, Arison BH, Davies RO, Ferguson R, Zacchei AG. The metabolic disposition of (S)-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in rats, dogs, and humans. Drug Metab Dispos. 1980 May-Jun;8(3):163-7. PubMed PMID: 6104580. 9: McClure DE, Baldwin JJ, Randall WC, Lyon TF, Mensler K, Lundell GF, Raab AW, Gross D, Risley EA, Sweet CS, Williams M. Antihypertensive beta-adrenergic blocking agents: N-aralkyl analogues of 2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine. J Med Chem. 1983 May;26(5):649-57. PubMed PMID: 6132999.