T-0201, also known as TA 0201, is a highly potent, long-lasting, orally active and selective ETA receptor antagonist.. In binding studies, T-0201 competitively antagonized the specific binding of [125I]-ET-1 to human cloned ETA receptors (the Ki value was 0.015 +/- 0.004 nM). T-0201 weakly inhibited [125I]-ET-1-binding to human cloned ETB receptors; the Ki value was 41 +/- 21 nM. T-0201 also caused the inhibition of ET-1-induced contraction of the isolated rabbit pulmonary artery (pA2 = 5.7 +/- 0.3).
MedKoo Cat#: 526689
Name: T-0201
CAS#: 169679-53-2
Chemical Formula: C27H28BrN5O5S
Exact Mass: 613.0995
Molecular Weight: 614.52
Elemental Analysis: C, 52.77; H, 4.59; Br, 13.00; N, 11.40; O, 13.02; S, 5.22
The following data is based on the product molecular weight 614.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
