Synonym
CP-809101; CP 809101; CP809101. CP-809101 HCl; C-809101 HCl; CP 809101 HCl; CP-809101 hydrochloride;
IUPAC/Chemical Name
2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride
InChi Key
NMUNRTCTDLORDR-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17ClN4O.ClH/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20;/h1-3,8-10,17H,4-7,11H2;1H
SMILES Code
ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1.[H]Cl
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
34.1 |
100.00 |
| Water |
6.8 |
20.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
341.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PJ, Pratt WE. Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT(2C) receptor agonists. Psychopharmacology (Berl). 2016 May 30. [Epub ahead of print] PubMed PMID: 27241709.
2: Jukic MM, Carrillo-Roa T, Bar M, Becker G, Jovanovic VM, Zega K, Binder EB, Brodski C. Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder. Neuropsychopharmacology. 2015 Mar;40(4):839-48. doi: 10.1038/npp.2014.244. Epub 2014 Sep 22. PubMed PMID: 25241801; PubMed Central PMCID: PMC4330498.
3: Goda SA, Piasecka J, Olszewski M, Kasicki S, Hunt MJ. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 2013 Jul;228(2):271-82. doi: 10.1007/s00213-013-3057-1. Epub 2013 Mar 23. PubMed PMID: 23525524; PubMed Central PMCID: PMC3693439.
4: Canal CE, Booth RG, Morgan D. Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model. Neuropharmacology. 2013 Jul;70:112-21. doi: 10.1016/j.neuropharm.2013.01.007. Epub 2013 Jan 23. PubMed PMID: 23353901; PubMed Central PMCID: PMC3754837.
5: Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ. Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. doi: 10.1007/s00213-012-2919-2. Epub 2012 Nov 25. PubMed PMID: 23184281.
6: Greenwood BN, Strong PV, Loughridge AB, Day HE, Clark PJ, Mika A, Hellwinkel JE, Spence KG, Fleshner M. 5-HT2C receptors in the basolateral amygdala and dorsal striatum are a novel target for the anxiolytic and antidepressant effects of exercise. PLoS One. 2012;7(9):e46118. doi: 10.1371/journal.pone.0046118. Epub 2012 Sep 25. PubMed PMID: 23049953; PubMed Central PMCID: PMC3458100.
7: Schulz SB, Heidmann KE, Mike A, Klaft ZJ, Heinemann U, Gerevich Z. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol. 2012 Dec;167(7):1480-91. doi: 10.1111/j.1476-5381.2012.02107.x. PubMed PMID: 22817643; PubMed Central PMCID: PMC3514761.
8: Strong PV, Greenwood BN, Fleshner M. The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats. Psychopharmacology (Berl). 2009 May;203(4):665-75. doi: 10.1007/s00213-008-1413-3. Epub 2008 Nov 27. PubMed PMID: 19037632.
