MedKoo Cat#: 525630 | Name: Minalrestat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Minalrestat, also known as ARI-509; WAY-121509; WAY-ARI-509; WAYARI-509, is an aldose reductase inhibitor which corrects the impaired microvascular reactivity in diabetes.

Chemical Structure

Minalrestat
Minalrestat
CAS#129688-50-2

Theoretical Analysis

MedKoo Cat#: 525630

Name: Minalrestat

CAS#: 129688-50-2

Chemical Formula: C19H11BrF2N2O4

Exact Mass: 447.9870

Molecular Weight: 449.21

Elemental Analysis: C, 50.80; H, 2.47; Br, 17.79; F, 8.46; N, 6.24; O, 14.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Minalrestat, ARI-509; WAY-121509; WAY-ARI-509; WAYARI-509; ARI509; WAY121509; WAYARI-509; WAYARI509.
IUPAC/Chemical Name
2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H-spiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'(2H)-tetraone
InChi Key
BMHZAHGTGIZZCT-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)
SMILES Code
O=C1N(CC2=CC=C(Br)C=C2F)C(C3(C(NC(C3)=O)=O)C4=C1C=CC(F)=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 449.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A. Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors. Proteins. 2004 Jun 1;55(4):805-13. PubMed PMID: 15146479. 2: Cruz JW, Soto-Suazo MW, Hohman TC, Akamine EH, Zorn TT, Fortes ZB. Minalrestat and leukocyte migration in diabetes mellitus. Diabetes Metab Res Rev. 2003 May-Jun;19(3):223-31. PubMed PMID: 12789656. 3: Akamine EH, Hohman TC, Nigro D, Carvalho MH, de Cássia Tostes R, Fortes ZB. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. PubMed PMID: 12604701. 4: Tse SY, Whetsel R. Determination of minalrestat (an aldose reductase inhibitor) in rat, dog and human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 May 8;709(1):127-35. PubMed PMID: 9653934.