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MedKoo Cat#: 122420 | Name: MIND4-17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MIND4-17 is a SIR2 inhibitor for treatment of Huntington’s disease

Chemical Structure

MIND4-17
MIND4-17
CAS#345989-24-4

Theoretical Analysis

MedKoo Cat#: 122420

Name: MIND4-17

CAS#: 345989-24-4

Chemical Formula: C20H15N5O3S

Exact Mass: 405.0896

Molecular Weight: 405.43

Elemental Analysis: C, 59.25; H, 3.73; N, 17.27; O, 11.84; S, 7.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MIND 417; MIND-417; MIND4-17; MIND 4-17
IUPAC/Chemical Name
5-nitro-2-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)pyridine
InChi Key
OZUBDKIROJPQGE-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15N5O3S/c26-25(27)16-11-12-19(21-13-16)29-20-23-22-18(14-28-17-9-5-2-6-10-17)24(20)15-7-3-1-4-8-15/h1-13H,14H2
SMILES Code
O=[N+](C1=CN=C(SC2=NN=C(COC3=CC=CC=C3)N2C4=CC=CC=C4)C=C1)[O-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen N, Li Y, Huang N, Yao J, Luo WF, Jiang Q. The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury. J Cell Physiol. 2020 Oct;235(10):7204-7213. doi: 10.1002/jcp.29619. Epub 2020 Feb 5. PMID: 32020639. 2: Li C, Yan K, Wang W, Bai Q, Dai C, Li X, Huang D. MIND4-17 protects retinal pigment epithelium cells and retinal ganglion cells from UV. Oncotarget. 2017 Sep 21;8(52):89793-89801. doi: 10.18632/oncotarget.21131. PMID: 29163788; PMCID: PMC5685709. 3: Guo S, Fei HD, Ji F, Chen FL, Xie Y, Wang SG. Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress. Oncotarget. 2017 Nov 10;8(62):105662-105672. doi: 10.18632/oncotarget.22360. PMID: 29285281; PMCID: PMC5739668.