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MedKoo Cat#: 524757 | Name: Clioxanide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clioxanide is a derivative of diiodobenzanilide. It is used as an antihelmintic against Fasciola hepatica and Haemonchus contortus.

Chemical Structure

Clioxanide
Clioxanide
CAS#14437-41-3

Theoretical Analysis

MedKoo Cat#: 524757

Name: Clioxanide

CAS#: 14437-41-3

Chemical Formula: C15H10ClI2NO3

Exact Mass: 540.8439

Molecular Weight: 541.51

Elemental Analysis: C, 33.27; H, 1.86; Cl, 6.55; I, 46.87; N, 2.59; O, 8.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Clioxanide; Tremerad; SYD 230; Clioxanidum [INN-Latin]; Clioxanida [INN-Spanish]; SYD-230; EINECS 238-414-0.
IUPAC/Chemical Name
2-(4-Chlorphenylcarbamoyl)-4,6-diodphenyl acetat
InChi Key
ICKMASVVMCGZLR-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10ClI2NO3/c1-8(20)22-14-12(6-10(17)7-13(14)18)15(21)19-11-4-2-9(16)3-5-11/h2-7H,1H3,(H,19,21)
SMILES Code
c1(c(c(cc(c1)I)I)OC(C)=O)C(Nc1ccc(Cl)cc1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 541.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Douch PG. The metabolism of the anthelmintics clioxanide and resorantel and related compounds in vitro by Moniezia expansa, Ascaris suum and mouse- and sheep-liver enzymes. Xenobiotica. 1979 Apr;9(4):263-8. PubMed PMID: 483862. 2: Foreyt WJ, Todd AC. Effects of six fasciolicides against Fascioloides magna In white-tailed deer. J Wildl Dis. 1976 Jul;12(3):361-6. PubMed PMID: 16498878. 3: Campbell NJ, Brotowidjoyo MD. The efficiency of clioxanide and rafoxanide against Fasciola hepatica in sheep by different routes of administration. Aust Vet J. 1975 Nov;51(11):500-3. PubMed PMID: 1220653. 4: Presidente PJ, Knapp SE, Schlegel MW, Armstrong JN. Anthelmintic efficacy of clioxanide against experimentally induced Fasciola hepatica infections in calves. Am J Vet Res. 1972 Aug;33(8):1593-601. PubMed PMID: 5047118. 5: Campbell NJ, Hotson IK. The anthelmintic efficiency of clioxanide and rafoxanide against Fasciola hepatica and Haemonchus contortus in sheep. Aust Vet J. 1971 Jan;47(1):5-8. PubMed PMID: 5542375. 6: Pearson IG, Whitlock HV, DeGoosh CP, Farrington KJ, Jones RC, Haigh JA. Clioxanide, a new anthelmintic active against Fasciola hepatica and Haemonchus contortus in sheep. Aust Vet J. 1970 Oct;46(10):480-4. PubMed PMID: 5481928. 7: Symons LE, Roseby FB. The use of clioxanide as an anthelmintic in sheep infected with Haemonchus contortus. Aust Vet J. 1969 Aug;45(8):385. PubMed PMID: 5389344. 8: Boray JC, Roseby FB. The effect of the route of administration on the efficiency of clioxanide against immature Fasciola hepatica in sheep. Aust Vet J. 1969 Aug;45(8):363-5. PubMed PMID: 5389338. 9: Tewari HC. Comparative efficiency of hexachloroethane and clioxanide against Fasciola hepatica in the rat. Aust Vet J. 1968 Sep;44(9):401-2. PubMed PMID: 5681445.