ML-347, also known as LDN193719, is a potent and selective bone morphogenetic protein receptor (BMP) inhibitor that inhibits ALK1 and ALK2 with IC50 values of 46 and 32 nM, respectively. ML347 shows >300-fold selectivity for ALK2.
MedKoo Cat#: 406750
Name: ML-347
CAS#: 1062368-49-3
Chemical Formula: C22H16N4O
Exact Mass: 352.1324
Molecular Weight: 352.40
Elemental Analysis: C, 74.98; H, 4.58; N, 15.90; O, 4.54
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 5.0 | 14.19 | ||
| DMSO | 9.3 | 26.28 | ||
| DMSO:PBS (pH 7.2) (1:2) | 0.3 | 0.71 |
The following data is based on the product molecular weight 352.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
