MedKoo Cat#: 574671 | Name: Dihydrochlamydocin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydrochlamydocin is a cyclic tetrapeptide with putative histone deacetylase (HDAC) inhibitory activity. Naturally derived cyclic tetrapeptides and their synthetic analogs have demonstrated potent antiparasitic and phytotoxic activity by inhibiting HDACs.

Chemical Structure

Dihydrochlamydocin
CAS#157618-75-2

Theoretical Analysis

MedKoo Cat#: 574671

Name: Dihydrochlamydocin

CAS#: 157618-75-2

Chemical Formula: C28H40N4O6

Exact Mass: 528.2948

Molecular Weight: 528.65

Elemental Analysis: C, 63.62; H, 7.63; N, 10.60; O, 18.16

Price and Availability

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1mg USD 550.00 Back order
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Related CAS #
No Data
Synonym
Dihydrochlamydocin
IUPAC/Chemical Name
(3S,9S,14aR)-9-benzyl-3-((R)-7-hydroxy-6-oxooctyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone
InChi Key
UXOLDMJAFJDQSE-RYFAJOAYSA-N
InChi Code
InChI=1S/C28H40N4O6/c1-18(33)23(34)15-9-5-8-13-20-24(35)31-28(2,3)27(38)30-21(17-19-11-6-4-7-12-19)26(37)32-16-10-14-22(32)25(36)29-20/h4,6-7,11-12,18,20-22,33H,5,8-10,13-17H2,1-3H3,(H,29,36)(H,30,38)(H,31,35)/t18-,20+,21+,22-/m1/s1
SMILES Code
O=C(N[C@@H](CCCCCC([C@H](O)C)=O)C(NC1(C)C)=O)[C@]2([H])N(CCC2)C([C@H](CC3=CC=CC=C3)NC1=O)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Dihydrochlamydocin is a cyclic tetrapeptide with putative histone deacetylase (HDAC) inhibitory activity.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 528.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Di Micco, S., Terracciano, S., Bruno, I., et al. Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222. Bioorg. Med. Chem. 16(18), 8635-8642 (2008). 2. Traoré, M., Mietton, F., Maubon, D., et al. Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides. J. Org. Chem. 78(8), 3655-3675 (2013).