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MedKoo Cat#: 463968 | Name: Piroxicam-d3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piroxicam-d3 is intended for use as an internal standard for the quantification of piroxicam by GC- or LC-MS. Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 240 and ~470 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered at doses of 1, 2.5, and 5 mg/kg. Formulations containing piroxicam have been used in the treatment of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.

Chemical Structure

Piroxicam-d3
Piroxicam-d3
CAS#942047-64-5

Theoretical Analysis

MedKoo Cat#: 463968

Name: Piroxicam-d3

CAS#: 942047-64-5

Chemical Formula: C15H10D3N3O4S

Exact Mass: 334.0815

Molecular Weight: 334.36

Elemental Analysis: C, 53.88; H, 4.82; N, 12.57; O, 19.14; S, 9.59

Price and Availability

Size Price Availability Quantity
1mg USD 500.00 2 Weeks
5mg USD 1,050.00 2 Weeks
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Related CAS #
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Synonym
Piroxicam-d3; Piroxicam d3;
IUPAC/Chemical Name
4-hydroxy-2-(methyl-d3)-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide
InChi Key
QYSPLQLAKJAUJT-FIBGUPNXSA-N
InChi Code
InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)/i1D3
SMILES Code
OC(C1=CC=CC=C1S2(=O)=O)=C(N2C([2H])([2H])[2H])C(NC3=CC=CC=N3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Grada A, Feldman SR, Bragazzi NL, Damiani G. Patient-reported outcomes of topical therapies in actinic keratosis: a systematic review. Dermatol Ther. 2021 Feb 2:e14833. doi: 10.1111/dth.14833. Epub ahead of print. PMID: 33527673. 2: Mbah C, Ogbonna J, Nzekwe I, Ugwu G, Ezeh R, Builders P, Attama A, Adikwu M, Ofoefule S. Nanovesicle formulation enhances anti-inflammatory and safe use of piroxicam. Pharm Nanotechnol. 2021 Jan 29. doi: 10.2174/2211738509666210129151844. Epub ahead of print. PMID: 33511937. 3: Wada A, Nagata K. Huge myxosarcoma arising from the greater omentum in a dog. J Vet Med Sci. 2021 Jan 27. doi: 10.1292/jvms.20-0509. Epub ahead of print. PMID: 33504735. 4: Agostinho DAS, Jesus AR, Silva ABP, Esperança JMSS, Paiva A, Duarte ARC, Reis PM. Improvement of new dianionic ionic liquids vs monoanionic in solubility of poorly water-soluble drugs. J Pharm Sci. 2021 Jan 20:S0022-3549(21)00029-0. doi: 10.1016/j.xphs.2021.01.014. Epub ahead of print. PMID: 33484731. 5: Lin L, Xu L, Kuang H, Xiao J, Xu C. Ultrasensitive and simultaneous detection of 6 nonsteroidal anti-inflammatory drugs by colloidal gold strip sensor. J Dairy Sci. 2021 Jan 14:S0022-0302(21)00058-8. doi: 10.3168/jds.2020-19500. Epub ahead of print. PMID: 33455779. 6: Robert C, Fraser-Miller SJ, Be Rziņš KR, Okeyo PO, Rantanen J, Rades T, Gordon KC. Monitoring the Isothermal Dehydration of Crystalline Hydrates Using Low-Frequency Raman Spectroscopy. Mol Pharm. 2021 Jan 6. doi: 10.1021/acs.molpharmaceut.0c01126. Epub ahead of print. PMID: 33406363. 7: Mobashar A, Shabbir A, Shahzad M, Saeed-Ul-Hassan. Evaluation of Immunomodulatory and Antiarthritic Potential of Trigonella gharuensis Extracts. Evid Based Complement Alternat Med. 2020 Dec 12;2020:8836080. doi: 10.1155/2020/8836080. PMID: 33381210; PMCID: PMC7749762. 8: Lachowicz D, Kaczyńska A, Bodzon-Kulakowska A, Karewicz A, Wirecka R, Szuwarzyński M, Zapotoczny S. Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam. Int J Mol Sci. 2020 Dec 18;21(24):9664. doi: 10.3390/ijms21249664. PMID: 33352956; PMCID: PMC7767055. 9: Ahmed S, Kassem MA, Sayed S. Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation. Int J Nanomedicine. 2020 Dec 8;15:9783-9798. doi: 10.2147/IJN.S278688. PMID: 33324052; PMCID: PMC7733410. 10: Alazzouni AS, Fathalla AS, Gabri MS, Dkhil MA, Hassan BN. Role of bone marrow derived-mesenchymal stem cells against gastric ulceration: Histological, immunohistochemical and ultrastructural study. Saudi J Biol Sci. 2020 Dec;27(12):3456-3464. doi: 10.1016/j.sjbs.2020.09.044. Epub 2020 Sep 26. PMID: 33304156; PMCID: PMC7715057. 11: Hirakawa Y, Ueda H, Takata Y, Minamihata K, Wakabayashi R, Kamiya N, Goto M. Co-amorphous formation of piroxicam-citric acid to generate supersaturation and improve skin permeation. Eur J Pharm Sci. 2021 Mar 1;158:105667. doi: 10.1016/j.ejps.2020.105667. Epub 2020 Dec 6. PMID: 33296711. 12: Mostafa A, Kandeil A, A M M Elshaier Y, Kutkat O, Moatasim Y, Rashad AA, Shehata M, Gomaa MR, Mahrous N, Mahmoud SH, GabAllah M, Abbas H, Taweel AE, Kayed AE, Kamel MN, Sayes ME, Mahmoud DB, El-Shesheny R, Kayali G, Ali MA. FDA- Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2. Pharmaceuticals (Basel). 2020 Dec 4;13(12):443. doi: 10.3390/ph13120443. PMID: 33291642; PMCID: PMC7761982. 13: Bhattacharya P, Kumar Pandey A, Paul S, Patnaik R. Corrigendum to "Does Piroxicam really protect ischemic neurons and influence neuronal firing in cerebral ischemia? An exploration towards therapeutics" [Med Hypotheses 81 (2013) 429-435]. Med Hypotheses. 2020 Nov;144:110266. doi: 10.1016/j.mehy.2020.110266. Epub 2020 Sep 17. Erratum for: Med Hypotheses. 2013 Sep;81(3):429-35. PMID: 33254570. 14: Kang EA, Choi HI, Hong SW, Kang S, Jegal HY, Choi EW, Park BS, Kim JS. Extracellular Vesicles Derived from Kefir Grain Lactobacillus Ameliorate Intestinal Inflammation via Regulation of Proinflammatory Pathway and Tight Junction Integrity. Biomedicines. 2020 Nov 20;8(11):522. doi: 10.3390/biomedicines8110522. PMID: 33233771; PMCID: PMC7709018. 15: Sudi IY, Ahmed MU, Adzu B. Sphaeranthus senegalensis DC: Evaluation of chemical constituents, oral safety, gastroprotective activity, and mechanism of action of its hydroethanolic extract. J Ethnopharmacol. 2021 Mar 25;268:113597. doi: 10.1016/j.jep.2020.113597. Epub 2020 Nov 19. PMID: 33221497. 16: Zhao L, Mustapha O, Shafique S, Jamshaid T, Din FU, Mehmood Y, Anwer K, Yousafi QUA, Hussain T, Khan IU, Ghori MU, Shahzad Y, Yousaf AM. Electrospun Gelatin Nanocontainers for Enhanced Biopharmaceutical Performance of Piroxicam: In Vivo and In Vitro Investigations. Int J Nanomedicine. 2020 Nov 10;15:8819-8828. doi: 10.2147/IJN.S271938. PMID: 33204090; PMCID: PMC7667701. 17: Yazdi S, Chen DJ, Putnam D. Microparticle fabricated from a series of symmetrical lipids based on dihydroxyacetone form textured architectures. J Control Release. 2020 Nov 12:S0168-3659(20)30661-1. doi: 10.1016/j.jconrel.2020.11.012. Epub ahead of print. PMID: 33188826. 18: Xiong H, Liu G, Xiao J, Han Y, Liu T, Wan J, Yang J, Ding J, Dong X. Recurrence of Stevens-Johnson syndrome/toxic epidermal necrolysis induced by allopurinol and piroxicam. Eur J Dermatol. 2020 Oct 1;30(5):620-621. doi: 10.1684/ejd.2020.3857. PMID: 33185537. 19: Kamble D, Singhavi D, Tapadia S, Khan S. Investigation of Pectin- Hydroxypropyl Methylcellulose-Coated Floating Beads for Pulsatile Release of Piroxicam. Turk J Pharm Sci. 2020 Oct;17(5):542-548. doi: 10.4274/tjps.galenos.2019.99896. Epub 2020 Oct 30. PMID: 33177936; PMCID: PMC7650729. 20: Çelebİer M, Nennİ M, Kaplan O, Akgeyİk E, Kaynak MS, Şahİn S. Determination of the Physicochemical Properties of Piroxicam. Turk J Pharm Sci. 2020 Oct;17(5):535-541. doi: 10.4274/tjps.galenos.2019.82335. Epub 2020 Oct 30. PMID: 33177935; PMCID: PMC7650726.