Synonym
CI 924; CI924; CI-924; EINECS 279-174-7.
IUPAC/Chemical Name
5,5'-((1,1'-Biphenyl)-2,5-diylbis(oxy))bis(2,2-dimethylpentanoic acid)
InChi Key
RPGQBVHHFQUGBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H34O6/c1-25(2,23(27)28)14-8-16-31-20-12-13-22(21(18-20)19-10-6-5-7-11-19)32-17-9-15-26(3,4)24(29)30/h5-7,10-13,18H,8-9,14-17H2,1-4H3,(H,27,28)(H,29,30)
SMILES Code
c1c(c2ccccc2)c(ccc1OCCCC(C(=O)O)(C)C)OCCCC(C(=O)O)(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
442.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Harbarth S, Szucs T, Berger K, Jilg W. The economic burden of hepatitis B in Germany. Eur J Epidemiol. 2000 Feb;16(2):173-7. PubMed PMID: 10845268.
2: Hofstra AH, King LM, Walker RM. Early effects of CI-924 on hepatic peroxisome proliferation, microsomal enzyme induction, PCNA, and apoptosis in B6C3F1 mice and Wistar rats. Arch Toxicol. 1997;71(4):250-7. PubMed PMID: 9101042.
3: Walker RM, Wojcinski ZW, Hofstra AH, King LM, Rogers JE, Baker KW, Chang PK, Smith GS. Hepatotumorigenicity and peroxisome proliferation induced by the hypolipidemic CI-924 in a two-year study in male and female B6C3F1 mice. Toxicol Pathol. 1996 May-Jun;24(3):265-72. PubMed PMID: 8736381.
4: Hofstra AH, King LM, Walker RM. Peroxisome proliferation and microsomal enzyme induction by the hypolipidemic CI-924 in rats and mice: relationship to tumorgenicity. Fundam Appl Toxicol. 1995 Sep;27(2):277-86. PubMed PMID: 8529824.
5: Corder CN, Kloer HU, Price MD. CI-924 effects on plasma lipids in patients with type II and type IV hyperlipoproteinaemia. Eur J Clin Pharmacol. 1989;37(5):477-81. PubMed PMID: 2598985.
6: Sircar I, Hoefle M, Maxwell RE. Phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s: agents that elevate high-density lipoproteins. J Med Chem. 1983 Jul;26(7):1020-7. PubMed PMID: 6864730.
