CI 924 | CAS#79520-77-7 | hypolipidemic agent

MedKoo Cat#: 524716 | Name: CI 924

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CI 924 is hypolipidemic agent. CI 924 elevated anti-atherogenic HDL and lowered VLDL at 600 mg/day.

Chemical Structure

CI 924

CAS#79520-77-7

Theoretical Analysis

MedKoo Cat#: 524716

Name: CI 924

CAS#: 79520-77-7

Chemical Formula: C26H34O6

Exact Mass: 442.2355

Molecular Weight: 442.54

Elemental Analysis: C, 70.56; H, 7.74; O, 21.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CI 924; CI924; CI-924; EINECS 279-174-7.

IUPAC/Chemical Name

5,5'-((1,1'-Biphenyl)-2,5-diylbis(oxy))bis(2,2-dimethylpentanoic acid)

InChi Key

RPGQBVHHFQUGBU-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H34O6/c1-25(2,23(27)28)14-8-16-31-20-12-13-22(21(18-20)19-10-6-5-7-11-19)32-17-9-15-26(3,4)24(29)30/h5-7,10-13,18H,8-9,14-17H2,1-4H3,(H,27,28)(H,29,30)

SMILES Code

c1c(c2ccccc2)c(ccc1OCCCC(C(=O)O)(C)C)OCCCC(C(=O)O)(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 442.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Harbarth S, Szucs T, Berger K, Jilg W. The economic burden of hepatitis B in Germany. Eur J Epidemiol. 2000 Feb;16(2):173-7. PubMed PMID: 10845268. 2: Hofstra AH, King LM, Walker RM. Early effects of CI-924 on hepatic peroxisome proliferation, microsomal enzyme induction, PCNA, and apoptosis in B6C3F1 mice and Wistar rats. Arch Toxicol. 1997;71(4):250-7. PubMed PMID: 9101042. 3: Walker RM, Wojcinski ZW, Hofstra AH, King LM, Rogers JE, Baker KW, Chang PK, Smith GS. Hepatotumorigenicity and peroxisome proliferation induced by the hypolipidemic CI-924 in a two-year study in male and female B6C3F1 mice. Toxicol Pathol. 1996 May-Jun;24(3):265-72. PubMed PMID: 8736381. 4: Hofstra AH, King LM, Walker RM. Peroxisome proliferation and microsomal enzyme induction by the hypolipidemic CI-924 in rats and mice: relationship to tumorgenicity. Fundam Appl Toxicol. 1995 Sep;27(2):277-86. PubMed PMID: 8529824. 5: Corder CN, Kloer HU, Price MD. CI-924 effects on plasma lipids in patients with type II and type IV hyperlipoproteinaemia. Eur J Clin Pharmacol. 1989;37(5):477-81. PubMed PMID: 2598985. 6: Sircar I, Hoefle M, Maxwell RE. Phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s: agents that elevate high-density lipoproteins. J Med Chem. 1983 Jul;26(7):1020-7. PubMed PMID: 6864730.