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MedKoo Cat#: 524651 | Name: CGP-20712

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP-20712 is a beta1-selective beta-adrenoceptor antagonist.

Chemical Structure

CGP-20712
CGP-20712
CAS#137888-49-4 (free base)

Theoretical Analysis

MedKoo Cat#: 524651

Name: CGP-20712

CAS#: 137888-49-4 (free base)

Chemical Formula: C23H25F3N4O5

Exact Mass: 494.1777

Molecular Weight: 494.46

Elemental Analysis: C, 55.87; H, 5.10; F, 11.53; N, 11.33; O, 16.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1216905-73-5(2HCl) 137888-49-4 (free Base) 105737-62-0 (ethanesulfonate)
Synonym
CGP-20712; CGP 20712; CGP20712; UNII-SIO2UEZ19H.
IUPAC/Chemical Name
2-hydroxy-5-(2-((2-hydroxy-3-(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenoxy)propyl)amino)ethoxy)benzamide
InChi Key
GKJZEKSHCJELPL-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H25F3N4O5/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33)
SMILES Code
Cn1cc(nc1c2ccc(cc2)OCC(CNCCOc3ccc(c(c3)C(=O)N)O)O)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 494.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dooley DJ, Bittiger H. Quantitative assessment of central beta 1- and beta 2-adrenoceptor regulation using CGP 20712 A. J Pharmacol Methods. 1987 Sep;18(2):131-6. PubMed PMID: 2887701. 2: Dooley DJ, Bittiger H, Reymann NC. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. PubMed PMID: 2877892. 3: Kaumann AJ. The beta 1-adrenoceptor antagonist CGP 20712 A unmasks beta 2-adrenoceptors activated by (-)-adrenaline in rat sinoatrial node. Naunyn Schmiedebergs Arch Pharmacol. 1986 Apr;332(4):406-9. PubMed PMID: 2874503.