CGP 20712A Dihydrochoride | CAS#1216905-73-5 | β1-adrenoceptor Agonist | 137888-49-4

MedKoo Cat#: 513681 | Name: CGP 20712A Dihydrochoride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 20712A Dihydrochoride is a potent and selective antagonist of β1-adrenoceptor with IC50 value of 0.7 nM .

Chemical Structure

CGP 20712A Dihydrochoride

CAS#1216905-73-5(2HCl)

Theoretical Analysis

MedKoo Cat#: 513681

Name: CGP 20712A Dihydrochoride

CAS#: 1216905-73-5(2HCl)

Chemical Formula: C23H27Cl2F3N4O5

Exact Mass: 0.0000

Molecular Weight: 567.38

Elemental Analysis: C, 48.69; H, 4.80; Cl, 12.50; F, 10.05; N, 9.87; O, 14.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1216905-73-5(2HCl) 137888-49-4 (free Base) 105737-62-0 (ethanesulfonate)

Synonym

CGP 20712A Dihydrochoride; CGP 20712ADihydrochoride; CGP 20712A; CGP20712A; CGP-20712A.

IUPAC/Chemical Name

2-hydroxy-5-(2-((2-hydroxy-3-(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenoxy)propyl)amino)ethoxy)benzimidic acid dihydrochloride

InChi Key

PURFQCFKYNMIQF-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H25F3N4O5.2ClH/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33;;/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33);2*1H

SMILES Code

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 567.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Janssens K, Boussemaere M, Wagner S, Kopka K, Denef C. Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels. Endocrinology. 2008 May;149(5):2391-402. doi: 10.1210/en.2007-1397. PubMed PMID: 18202135. 2: Elsinga PH, Van Waarde A, Visser GM, Vaalburg W. Synthesis and preliminary evaluation of (R,S)-1-[2-((carbamoyl-4-hydroxy)phenoxy)-ethylamino]-3-[4-(1-[11C]-met hyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol ([11C]CGP 20712A) as a selective beta 1-adrenoceptor ligand for PET. Nucl Med Biol. 1994 Feb;21(2):211-7. PubMed PMID: 9234285.