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MedKoo Cat#: 524581 | Name: Cefovecin Sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefovecin, also known as UK-287074, is an antibiotic of the cephalosporin class. Cefovecin interferes with the synthesis of bacterial cell walls, by binding to penicillin binding proteins. Due to high protein-binding, it is not effective against species of Pseudomonas or Enterococcus. The maximum anti-bacterial activity occurs approximately two days after cefovecin has been administered. It is used to treat skin infections caused by Pasteurella multocida in cats, and Staphylococcus intermedius and Streptococcus canis in dogs.

Chemical Structure

Cefovecin Sodium
Cefovecin Sodium
CAS#141195-77-9 (sodium)

Theoretical Analysis

MedKoo Cat#: 524581

Name: Cefovecin Sodium

CAS#: 141195-77-9 (sodium)

Chemical Formula: C17H18N5NaO6S2

Exact Mass: 475.0596

Molecular Weight: 475.48

Elemental Analysis: C, 42.94; H, 3.82; N, 14.73; Na, 4.84; O, 20.19; S, 13.49

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 6,250.00 2 Weeks
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Related CAS #
234096-34-5 (free base) 141195-77-9 (sodium)
Synonym
Cefovecin Sodium; UK-287,074-02; UK287,074-02; UK 287,074-02;; UK-287074; UK287074; UK 287074;; C13142; D01681.
IUPAC/Chemical Name
Sodium (6R,7R)-7-(((2Z)-(2-aminothiazol-4-yl)(methoxyimino)acetyl)amino)-8-oxo-3-((2S)-tetrahydrofuran-2-yl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
InChi Key
QRIBXVGHDLFNNE-VQWMGBAQSA-M
InChi Code
InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10-;/t9-,11+,15+;/m0./s1
SMILES Code
[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)[O-])[C@@H]3CCCO3)\c4csc(N)n4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
H2O 125.0 262.90
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 475.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nardini G, Barbarossa A, Dall'Occo A, Di Girolamo N, Cagnardi P, Magnone W, Bielli M, Roncada P, Zaghini A. Pharmacokinetics of cefovecin sodium after subcutaneous administration to Hermann's tortoises (Testudo hermanni). Am J Vet Res. 2014 Oct;75(10):918-23. doi: 10.2460/ajvr.75.10.918. PubMed PMID: 25255182. 2: Torres-Henderson C, Hesser J, Hyatt DR, Hawley J, Brewer M, Lappin MR. Pilot study to evaluate the role of Mycoplasma species in cat bite abscesses. J Feline Med Surg. 2014 Dec;16(12):997-1000. doi: 10.1177/1098612X14527475. Epub 2014 Mar 18. PubMed PMID: 24643287. 3: Silva RO, D'elia ML, de Magalhães Soares DF, Cavalcanti ÁR, Leal RC, Cavalcanti G, Pereira PL, Lobato FC. Clostridium difficile-associated diarrhea in an ocelot (Leopardus pardalis). Anaerobe. 2013 Apr;20:82-4. doi: 10.1016/j.anaerobe.2013.02.007. Epub 2013 Mar 4. PubMed PMID: 23467074. 4: Raabe BM, Lovaglio J, Grover GS, Brown SA, Boucher JF, Yuan Y, Civil JR, Gillhouse KA, Stubbs MN, Hoggatt AF, Halliday LC, Fortman JD. Pharmacokinetics of cefovecin in cynomolgus macaques (Macaca fascicularis), olive baboons (Papio anubis), and rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2011 May;50(3):389-95. PubMed PMID: 21640036; PubMed Central PMCID: PMC3103291. 5: Papp R, Popovic A, Kelly N, Tschirret-Guth R. Pharmacokinetics of Cefovecin in squirrel monkey (Saimiri sciureus), rhesus macaques (Macaca mulatta), and cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2010 Nov;49(6):805-8. PubMed PMID: 21205444; PubMed Central PMCID: PMC2994046. 6: Six R, Cleaver DM, Lindeman CJ, Cherni J, Chesebrough R, Papp G, Skogerboe TL, Weigel DJ, Boucher JF, Stegemann MR. Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds. J Am Vet Med Assoc. 2009 Jan 1;234(1):81-7. doi: 10.2460/javma.234.1.81. PubMed PMID: 19119969.